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Inflammation Mediators and the Inflammatory Reaction

Name: Inflammation Mediators and the Inflammatory Reaction
Keywords: Inflammation, Chlorpheniramine, Serotonin, Hydrocortisone, Methysergide, Cyproheptadine, Nicotinic Acids, Bradykinin, Fluoresceins, Niacin

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1964Publisher:American Medical Association (AMA)Journal:Archives of Dermatology, volume 89, page 55 (issn: 0003-987X,

Authors: Yehoshua Rapp; Lawrence Frank; Franklin S. Glickman; Laszlo Biro;

doi: 10.1001/archderm.1964.01590250061011

pmid: 14070838

Inflammation Mediators and the Inflammatory Reaction

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Abstract

A technique is described whereby the keratin layer of the skin is removed by stripping and the inflamed porous site is pretreated with inflammatory and antiinflammatory agents. Fluorescein and sodium anazolene (Coomassie Blue) are used as indicators of capillary permeability. By means of this technique the effects of inflammatory and antiinflammatory agents and the dynamics of inflammation of human skin is explored. Some of the effects of histamine, compound 48/80, nicotinic acid-furfuryl ointment, serotonin, and bradykinin on stripped skin and on capillary permeability are described, and their role as inflammatory agents is discussed. The action of antihistamine, antiserotonin, and hydrocortisone on inflamed skin and on some of the probable mediators of inflammation is also explored.

Keywords

Inflammation, Chlorpheniramine, Serotonin, Hydrocortisone, Methysergide, Cyproheptadine, Nicotinic Acids, Bradykinin, Fluoresceins, Niacin, Capillary Permeability, Anti-Allergic Agents, Histamine H1 Antagonists, Pathology, Humans, Furaldehyde, Inflammation Mediators, Phentolamine, Fluorescent Dyes, Histamine

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	9
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average