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Research on the development of the composition of an extemporaneous medicinal product with dexpanthenol

Research on the development of the composition of an extemporaneous medicinal product with dexpanthenol

Abstract

The prevalence of dermatological diseases is one of the problems of medical practice. Against the background of chronic stress disorders during the war, the incidence of contact dermatitis, atopic dermatitis, eczema, fungal lesions, psoriasis and other diseases has been increased. On the pharmaceutical market of Ukraine, soft dosage forms occupy approximately 10% among other drugs of industrial production. A large share also belongs to soft medicinal forms of extemporaneous production in Ukraine and abroad. The choice of the basis is depend on the physical and chemical properties of the active pharmaceutical ingredient, the pathological process, the method of application and the predicted pharmacological effect. One of the perspective directions of expansion and renewal of the prescription of extemporaneous medicine is the development of soft medicines on emulsion bases. The evolution of atopic dermatitis is a multifactorial process involving immunological defects, skin barrier dysfunction, genetic variation, and environmental factors. Dexpanthenol provides a noticeable moisturizing effect, due to its extremely hygroscopic characteristics, Topical application of dexpanthenol improves skin hydration and reduces trans-epidermal water loss, thus maintaining skin smoothness and elasticity. According to the assessment of average moisture retention for 5 hours, dexpanthenol provides a long-lasting effect of moisturizing tissues Key words: dermatological diseases; soft medicinal forms; emulsion

Поширення дерматологічних захворювань є однією з проблем медичної практики. На тлі хронічних стресових розладів під час війни підвищилась захворюваність населення на контактний, атопічний дерматит, екзему, грибкові ураження, псоріаз та інші хвороби. На фармацевтичному ринку України МЛФ займають приблизно 10 % серед інших препаратів промислового виробництва. Велика частка належить і МЛФ екстемпорального виготовлення як в Україні, так і за кордоном. Вибір основи залежить від фізико-хімічних властивостей АФІ, патологічного процесу, способу застосування та прогнозованого фармакологічного ефекту. Одним з перспективним напрямком розширення та оновлення рецептуру екстемпорального виробництва є розробка МЛЗ на емульсійних основах. Розвиток атопічного дерматину є багатофакторним процесом, що включає імунологічні дефекти, дисфункції шкірного бар’єру, генетичні варіації та чинники навколишнього середовища. Завдяки своїм надзвичайно гігроскопічним характеристикам декспантенол забезпечує помітний зволожувальний ефект. Місцеве застосування декспантенолу покращує гідратацію шкіри та зменшує транс епідермальну втрату води, таким чином зберігаючи гладкість і еластичність шкіри. Згідно з оцінкою середнього утримання вологи протягом 5 годин, декспантенол забезпечує тривалий ефект зволоження тканин.

Keywords

дерматологічні захворювання; м'які лікарські форми; емульсія., dermatological diseases; semi-solid dosage forms; emulsion.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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