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Аналіз маркерів міжклітинної адгезії у хворих на плоскоклітинний рак орофарингеальної ділянки

Authors: Shponka, I. S.; Kovtunenko, O. V.; Poslavska, J. V.; Berezniuk, D. V.; Tymchuk, S. M.;

Аналіз маркерів міжклітинної адгезії у хворих на плоскоклітинний рак орофарингеальної ділянки

Abstract

The authors have carried out a study of the level of the expression of the markers of intercellular adhesion in patients with planocellular carcinoma of the оrоpharyngeal area in order to detect clinicomorphological connections and an analysis of their significance between the level of the expression of E-kadgerin and ß-katenin, metastasizing and efficiency of chemoradiotherapy. A diagnostic and a prognostic value of every marker in relation to regional metastasizing and the effect of treatment have been established.

Проведено исследование уровня экспрессии маркеров межклеточной адгезии у больных плоскоклеточным раком орофарингеальной области для выявления клинико-морфологических связей и анализа их значимости между уровнем экспрессии Е-кадгерина и ß-катенина и метастазированием и эффективностью химиолучевого лечения. Установлено диагностическое значение, прогностическое значение каждого маркера относительно регионарного метастазирования и предсказательное относительно эффекта на проведенное химиолучевое лечение.

Проведено дослідження рівня експресії маркерів міжклітинної адгезії у хворих на плоскоклітинний рак орофарингеальної ділянки для виявлення клінічно-морфологічних зв'язків та аналізу їх значимості між рівнем експресії Е-кадгерину і ß-катеніну, метастазуванням і ефективністю хіміопроменевого лікування. Встановлено діагностичне і прогностичне значення кожного маркера відносно регіонарного метастазування та ефекту лікування.

Keywords

planocellular cancer of оrоpharyngeal area; E-kadgerin; ß-katenin, плоскоклеточный рак орофарингеальной области; Е-кадгерин; ß-катенин, плоскоклітинний рак орофарингеальної ділянки; Е-кадгерин; ß-катенін

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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