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Molecular-genetic markers of circadian rhythms under physiological conditions (a bibliographical review and the author’s own investigations)

Molecular-genetic markers of circadian rhythms under physiological conditions (a bibliographical review and the author’s own investigations)

Abstract

The review presents modern data concerning molecular-genetic markers of circadian rhythms. The role of melatonin in the organism and its participation in the synchronization of circadian rhythms has been characterized, melatonin receptors and genetic control of the effects of the hormone have been considered. The results of the authors’ own studies of the state of the gene of an early functional activity – с-fos in the neurons of the mammalian leading pacemaker of circadian rhythms – the suprachiasmatic nuclei of the hypothalamus.

В обзоре представлены современные данные о молекулярно-генетических маркерах циркадианных ритмов. Охарактеризована роль мелатонина в организме и его участие в синхронизации циркадианных ритмов. Рассмотрены мелатониновые рецепторы и генный контроль эффектов гормона. Приведены результаты собственных исследований состояния гена ранней функциональной активности c-fos в нейронах ведущего пейсмекера циркадианных ритмов млекопитающих – супрахиазматических ядер гипоталамуса.

В огляді представлені сучасні дані щодо молекулярно-генетичних маркерів циркадіанних ритмів. Охарактеризовано роль мелатоніну в організмі та його участь у синхронізації циркадіанних ритмів. Розглянуто мелатонінові рецептори та генний контроль ефектів гормону. Наведено результати власних досліджень стану гена ранньої функціональної активності c-fos у нейронах провідного пейсмекера циркадіанних ритмів ссавців – супрахіазматичних ядер гіпоталамуса.

Keywords

melatonin; circadian rhythms; molecular-genetic markers; c-fos, мелатонін; циркадіанні ритми; молекулярно-генетичні маркери; c-fos, мелатонин; циркадианные ритмы; молекулярно-генетические маркеры; c-fos

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold