
pmid: 15112010
pmc: PMC2585921
To examine the association between maternal smoking and non-syndromic orofacial clefts in infants.A meta-analysis of the association between maternal smoking during pregnancy was carried out using data from 24 case-control and cohort studies.Consistent, moderate and statistically significant associations were found between maternal smoking and cleft lip, with or without cleft palate (relative risk 1.34, 95% confidence interval 1.25-1.44) and between maternal smoking and cleft palate (relative risk 1.22, 95% confidence interval 1.10-1.35). There was evidence of a modest dose-response effect for cleft lip with or without cleft palate.The evidence of an association between maternal tobacco smoking and orofacial clefts is strong enough to justify its use in anti-smoking campaigns.
Cleft lip/epidemiology, Dose-response relationship, Cleft palate/epidemiology, Cleft Lip, Case-control studies, Global Health, Cohort Studies, Pregnancy, Smoking/adverse effects, Humans, Dose-Response Relationship, Drug, Smoking, Cleft lip/etiology, Infant, Newborn, Infant, Tobacco Products, Newborn, Cleft Palate, Meta-analysis, Cleft palate/etiology, Case-Control Studies, Cohort studies, Female, Drug, Public aspects of medicine, RA1-1270
Cleft lip/epidemiology, Dose-response relationship, Cleft palate/epidemiology, Cleft Lip, Case-control studies, Global Health, Cohort Studies, Pregnancy, Smoking/adverse effects, Humans, Dose-Response Relationship, Drug, Smoking, Cleft lip/etiology, Infant, Newborn, Infant, Tobacco Products, Newborn, Cleft Palate, Meta-analysis, Cleft palate/etiology, Case-Control Studies, Cohort studies, Female, Drug, Public aspects of medicine, RA1-1270
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