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Tobacco smoking and oral clefts: a meta-analysis.

Authors: Little Julian; Cardy Amanda; Munger Ronald G.;

Tobacco smoking and oral clefts: a meta-analysis.

Abstract

To examine the association between maternal smoking and non-syndromic orofacial clefts in infants.A meta-analysis of the association between maternal smoking during pregnancy was carried out using data from 24 case-control and cohort studies.Consistent, moderate and statistically significant associations were found between maternal smoking and cleft lip, with or without cleft palate (relative risk 1.34, 95% confidence interval 1.25-1.44) and between maternal smoking and cleft palate (relative risk 1.22, 95% confidence interval 1.10-1.35). There was evidence of a modest dose-response effect for cleft lip with or without cleft palate.The evidence of an association between maternal tobacco smoking and orofacial clefts is strong enough to justify its use in anti-smoking campaigns.

Related Organizations
Keywords

Cleft lip/epidemiology, Dose-response relationship, Cleft palate/epidemiology, Cleft Lip, Case-control studies, Global Health, Cohort Studies, Pregnancy, Smoking/adverse effects, Humans, Dose-Response Relationship, Drug, Smoking, Cleft lip/etiology, Infant, Newborn, Infant, Tobacco Products, Newborn, Cleft Palate, Meta-analysis, Cleft palate/etiology, Case-Control Studies, Cohort studies, Female, Drug, Public aspects of medicine, RA1-1270

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    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    249
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
249
Top 10%
Top 1%
Top 10%
Published in a Diamond OA journal