Biochemical markers in total intravenous anesthesia and propofol infusion syndrome: a preliminary study.
Copyright policy )Biochemical markers in total intravenous anesthesia and propofol infusion syndrome: a preliminary study.
To investigate biochemically whether total intravenous anesthesia (TIVA) using propofol creates a risk for Propofol Infusion Syndrome (PRIS).Forty patients scheduled for thyroid gland surgery were randomly assigned into Group T or C and premedicated 30 min before operation. Group T received remifentanyl hydrochloride, propofol infusion following anesthesia induction with propofol, vecuronium bromide and intubation. Group C received remifentanyl hydrochloride infusion, 1-1.5 MAC desflurane inhalation following anesthesia induction with thiopental, vecuronium bromide and intubation. Patients were respired 50% O2-air mixture. Blood gas, potassium, lactic acid, CK-MB, myoglobin, troponin I, total carnitine, triglyceride, creatinine concentrations were determined before operation, at intraoperative hour-2, postoperative hour-6.There were no significant differences between groups in potassium, lactic acid CK-MB, myoglobin, total carnitine or creatinine levels. Triglyceride level at intraoperative hour-2 increased in Group T, decreased at postoperative hour-6. Troponin I was higher in Group C than Group T at intraoperative hour-2 (p < 0.05). No asystole, bradycardia, arrhythmia, hypotension or change in urine color was detected.The present biochemical findings suggest that TIVA using propofol is safe.
- Pamukkale University Turkey
Male, vecuronium, drug safety, Time Factors, creatinine blood level, Turkey, Thyroid Gland, Pilot Projects, Risk Factors, middle aged, Anesthesia, Prospective Studies, Side effects, Infusions, Intravenous, intravenous anesthesia, lactate blood level, Propofol, clinical article, Respiration, Propofol infusion syndrome, potassium, adult, creatinine, article, Syndrome, Middle Aged, continuous infusion, Anesthetics, Combined, unclassified drug, female, creatine kinase MB, Artificial, Anesthesia, Intravenous, Biological Markers, Female, triacylglycerol, arterial gas, Intravenous, Anesthetics, Intravenous, remifentanil, propofol infusion syndrome, prospective study, Adult, Drug-Related Side Effects and Adverse Reactions, 610, male, Monitoring, Intraoperative, troponin I, Humans, controlled study, human, Adult; Analysis of Variance; Anesthesia, Intravenous/*adverse effects/methods; Anesthetics, Combined/administration & dosage/*adverse effects; Anesthetics, Intravenous/administration & dosage/*adverse effects; Biomarkers/blood; Chi-Square Distribution; Drug-Related Side Effects and Adverse Reactions/blood/*etiology/physiopathology; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Monitoring, Intraoperative/methods; Pilot Projects; Propofol/administration & dosage/*adverse effects; Pros, potassium blood level, anesthesia induction, Analysis of Variance, Chi-Square Distribution, propofol, carnitine, lactic acid, thiopental, pental sodyum, Respiration, Artificial, desflurane, biochemical marker, myoglobin, randomized controlled trial, thyroid surgery, Biomarkers
Male, vecuronium, drug safety, Time Factors, creatinine blood level, Turkey, Thyroid Gland, Pilot Projects, Risk Factors, middle aged, Anesthesia, Prospective Studies, Side effects, Infusions, Intravenous, intravenous anesthesia, lactate blood level, Propofol, clinical article, Respiration, Propofol infusion syndrome, potassium, adult, creatinine, article, Syndrome, Middle Aged, continuous infusion, Anesthetics, Combined, unclassified drug, female, creatine kinase MB, Artificial, Anesthesia, Intravenous, Biological Markers, Female, triacylglycerol, arterial gas, Intravenous, Anesthetics, Intravenous, remifentanil, propofol infusion syndrome, prospective study, Adult, Drug-Related Side Effects and Adverse Reactions, 610, male, Monitoring, Intraoperative, troponin I, Humans, controlled study, human, Adult; Analysis of Variance; Anesthesia, Intravenous/*adverse effects/methods; Anesthetics, Combined/administration & dosage/*adverse effects; Anesthetics, Intravenous/administration & dosage/*adverse effects; Biomarkers/blood; Chi-Square Distribution; Drug-Related Side Effects and Adverse Reactions/blood/*etiology/physiopathology; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Monitoring, Intraoperative/methods; Pilot Projects; Propofol/administration & dosage/*adverse effects; Pros, potassium blood level, anesthesia induction, Analysis of Variance, Chi-Square Distribution, propofol, carnitine, lactic acid, thiopental, pental sodyum, Respiration, Artificial, desflurane, biochemical marker, myoglobin, randomized controlled trial, thyroid surgery, Biomarkers
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