The chapters in this book provide coverage of the theoretical underpinnings and methodologies that typify research using a Spatially Integrated Social Science (SISS) approach. This insightful Handbook is intended chiefly as a primer for students and budding researchers who wish to investigate social, economic and behavioural phenomena by giving explicit consideration to the roles of space and place. The majority of chapters provide an emphasis on demonstrating applications of methods, tools and techniques that are used in SISS research, including long-established and relatively new approaches.