El síndrome overlap hepatitis autoinmune- cirrosis biliar primaria es una entidad caracterizada por manifestaciones clínicas, analíticas, inmunológicas e histológicas de ambas entidades. Presentamos el caso de una mujer de 26 años con una hepatitis aguda grave que cumple los criterios diagnósticos del síndrome de superposición y que respondió de forma satisfactoria al tratamiento con corticoides orales.

The autoinmune hepatitis-primary biliary cirrhosis overlap syndrome is an entity characterized by clinical, analytical, immunological and histological manifestations of both entities. We present the case of a 26-year-old woman with a serious acute hepatitis that fulfills the diagnostic criteria of the overlap syndrome and that showed a satisfactory response to oral corticoid therapy.