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Evaluación de los niveles de IgA secretora anti-Helicobacter pylori en oblación infantil venezolana

Authors: Cavazza, María Eugenia; Correnti, María; Ortiz, Diana; Perrone, Marianella; Daoud, Georgette; Urrestarazu, María Isabel; Serrano, Noris; +1 Authors

Evaluación de los niveles de IgA secretora anti-Helicobacter pylori en oblación infantil venezolana

Abstract

Helicobacter pylori está íntimamente asociado con el desarrollo de enfermedad úlcero-péptica y es un factor de riesgo en cáncer gástrico y MALToma. La IgA secretora es el principal anticuerpo en el sistema de las mucosas, jugando un papel importante como primera línea de defensa contra diferentes antígenos. El objetivo de este trabajo fue evaluar los niveles de IgA secretora específica anti-H. pylori en saliva de un grupo de niños con gastritis crónica histológica. Se evaluaron 30 niños con dolor abdominal recurrente (13 hembras y 17 varones con edad de 2 -15 años, media 7,3 años) provenientes de una consulta privada de la ciudad de Caracas y 30 niños asintomáticos del ambulatorio de la Colonia Tovar. En ambos grupos se realizó evaluación clínica, determinación de IgG anti- H. pylori en suero y de IgAs anti-H. pylori en saliva (ELISA). En el grupo sintomático se obtuvieron biopsias gástricas para evaluación histopatológica y prueba rápida de ureasa. En este grupo 53% de los niños presentaron gastritis crónica. 30% fueron H. pylori positivo y 23% H. pylori negativo, 17% de los niños presentó gastritis crónica activa H. pylori positivo. Se observó una tendencia al aumento de los niveles de IgAs relacionado con la severidad del hallazgo histológico; siendo estos niveles significativamente (p=0,0307) más elevados en pacientes con gastritis crónica activa H. pylori positivos que en el resto del grupo estudiado. Además; estos valores fueron significativamente más altos (p=0,0408) en pacientes H. pylori positivos con gastritis crónica activa que en pacientes con gastritis crónica. Estos resultados sugieren que los anticuerpos IgA secretores en saliva pueden jugar un papel importante en la inmunidad gástrica frente a la infección por H. pylori, asociado a la cronicidad y fase activa de la gastritis. Abstract Helicobacter pylori is associated with peptic ulcer disease and represents a risk factor in gastric cancer and maltoma. Secretory IgA, is the predominant gastrointestinal mucosal antibody, with an important effect against different antigens. The objetive of this study was to meassure the salival specific secretory IgA anti-H.pylori value in 30 children with chronic abdominal pain (13 female; 17 male, range 2-15 years old mean 7,3 years)and 30 children asymptomatic. Each child of the symptomatic group underwent clinical evaluation, serum IgG anti- H. pylori, salival IgAs anti-H. pylori (ELISA), gastric biopsy for histology, rapid urea test. Chronic gastritis was found in 53% (30% positive H. pylori, 23% negative H. pylori). Chronic active gastritis was detected in 17%, all positive for H. pylori. A significant tendency to increase secretory IgA levels, related to the severity of the histological gastric finding was observed (p=0,0307); which was significatly higher in children with positive H. pylori and chronic active gastritis than chronic gastritis (p=0,0408). These results probably reflect an important effect of the salival secretory IgA antibody in the gastric immunity against H. pylori infection associated with chronicity and activity of gastric infection.

Keywords

Helicobacter pylori, secretory IgA, children, gastritis, IgA secretora, niños

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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