Abstract Gitelman's syndrome is characterized by a mutation of SLC12A3 gene, which encodes the NaCl cotransporter of distal convoluted tubule resulting in hypokalaemia. During pregnancy its approach and treatment become a challenge. We report the case of a pregnant woman, with a history of previous abortions, who needed a tight analytical control with several hospital admissions throughout pregnancy and more agressive and controled oral and intravenous therapy, which allowed to preserve a good fetal development and normal delivery without complications. This disease in pregnant women has a good prognosis, although it imposes the need of a tight multidisciplinar follow-up.