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Особенности выявления латентно протекающей туберкулезной инфекции у больных с воспалительными заболеваниями кишечника

Authors: Babaeva, G.; Kerimova, K.; Ahmedzade, G.;

Особенности выявления латентно протекающей туберкулезной инфекции у больных с воспалительными заболеваниями кишечника

Abstract

Четверть населения мира имеет латентную туберкулезную инфекцию ЛТБИ. Системная иммуносупрессия является фактором риска реактивации ЛТБИ и развития активного туберкулеза и такая реактивация сопряжена с риском значительной заболеваемости и смертности. Несмотря на растущую глобальную заболеваемость воспалительными заболеваниями кишечника ВЗК и использование иммунносупрессивных методов лечения, текущие рекомендации по тестированию и лечению ЛТБИ у пациентов с ВЗК носят бессистемный характер из-за недостатка доказательств. В настоящее время основная трудность в точной диагностике воспалительных заболеваний кишечника ВЗК связана с высокой распространенностью заболеваний, приводящих к имитирующим ВЗК поражениям кишечника.

Un sfert din populația lumii are infecție latentă cu tuberculoză LTBI. Imunosupresia sistemică este un factor de risc pentru reactivarea LTBI și dezvoltarea tuberculozei active, iar o astfel de reactivare este asociată cu un risc de morbiditate și mortalitate semnificativă. În ciuda creșterii incidenței globale a bolii inflamatorii intestinale IBD și a utilizării terapiilor imunosupresoare, recomandările actuale pentru testarea și tratarea LTBI la pacienții cu IBD sunt inconsecvente din cauza lipsei de dovezi. În prezent, principala dificultate în diagnosticul precis al bolilor inflamatorii intestinale IBD este asociată cu prevalența ridicată a bolilor care duc la leziuni intestinale care imită IBD

A quarter of the worldrsquo;s population has latent tuberculosis infection LTBI. Systemic immunosuppression is a risk factor for the reactivation of LTBI and the development of active tuberculosis, and such reactivation is associated with a substantial risk of morbidity and mortality. Despite the growing global prevalence of inflammatory bowel diseases IBD and the use of immunosuppressive therapies, current recommendations for LTBI testing and treatment in IBD patients lack a systematic approach due to a lack of evidence. Currently, the main challenge in accurately diagnosing inflammatory bowel diseases IBD is the high prevalence of conditions that lead to intestinal lesions mimicking IBD.

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Keywords

туберкулез, латентная туберкулезная инфекция, abdominal tuberculosis, latent tuberculosis infection, gastrointestinal tuberculosis, tuberculoza, воспалительные заболевания кишечника, inflammatory bowel diseases, туберкулез кишечника, абдоминальный туберкулез, boală inflamatorie intestinală, tuberculoză abdominală, tuberculosis, tuberculoză intestinală, Infecţie tuberculoasă latentă

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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