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Aspecte de utilizare a antibioticelor la pacienții cu COVID-19.

Authors: Chianu, M.; Arteni, I.Ş.; Crasiuc, I.F.; Caracaş, A.; Vasilache, E.; Ștîrba, D.; Bacinschi, N.G.; +1 Authors

Aspecte de utilizare a antibioticelor la pacienții cu COVID-19.

Abstract

Использование антибактериальных препаратов у пациентов с COVID-19 противоречиво и требует накопления убедительных данных, чтобы избежать чрезмерного и необоснованного назначения. Клиническая картина является первым и наиболее убедительным аргументом для принятия решения о начале антибактериальной терапии, а лабораторные данные лейкоцитоз, СОЭ, лимфопения, С-реактивный белок, прокальцитонин и радиологические данные могут облегчить это решение при надлежащем и тщательном мониторировании. Бета-лактамные антибиотики пенициллины, цефалоспорины, в том числе защищенные, макролиды и фторхинолоны могут рассматриваться как препараты первой линии у госпитализированных больных с умеренной и тяжелой формой COVID19. При инфекции SARS CoV-2, продолжительность с момента появления симптомов и госпитализацией, может иметь решающее значение для начала антибактериального лечения в контексте выявления начала цитокинового шторма, для лечения которого необходимо применение стероидных противовоспалительных препаратов

Utilizarea preparatelor antibacteriene la pacienții cu COVID-19 este controversată și necesită acumularea de date convingătoare pentru evitarea prescrierilor excesive și inutile. Tabloul clinic pare a fi prima opțiune și cea mai convingătoare în luarea deciziei de inițiere a antibioticoterapiei, iar datele de laborator leucocitoza, VSH, limfopenia, proteina C-reactivă, procalcitonina și radiologice pot facilita luarea deciziei prin monitorizarea adecvată și minuțioasă. Beta-lactaminele penicilinele, cefalosporinele, inclusiv cele protejate, macrolidele și fluorochinolonele pot fi considerate preparate de primă intenție la pacienții în stare medie-gravă internați în secțiile de terapie. Durata infecției cu SARS CoV-2 de la debutul simptomelor până la momentul internării pot fi decisive pentru inițierea tratamentului antibacterian în contextul sesizării începutului furtunii citokinice, ce va necesita utilizarea antiinflamatoarelor steroidiene.

The use of antibacterial preparations in patients with COVID-19 is controversial and requires the accumulation of convincing data to avoid excessive and unnecessary prescriptions. The clinical picture seems to be the first and most convincing option in making the decision to initiate antibiotic therapy, and laboratory data leukocytosis, ESR, lymphopenia, C-reactive protein, procalcitonin and radiological data can facilitate this decision through proper monitoring. Beta-lactams penicillins, cephalosporins, including protected ones, macrolides and fluoroquinolones can be considered as firstline preparations in hospitalized patients with moderate and severe COVID-19. The duration of SARS CoV-2 infection between symptom onset and hospitalisation may be decisive for initiating antibacterial treatment in the context of noticing the onset of the cytokine storm, which will require the use of steroid anti-inflammatory drugs.

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Keywords

macrolides, антибиотикотерапия, peniciline, фторхинолоны, cefalosporine, fluorochinilone, SARS CoV-2, COVID-19, macrolide, antibioticoterapia, penicillins, пенициллины, cephalosporins, antibiotic therapy, макролиды, цефалоспорины, fluoroquinolones

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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