Darier's disease is a rare genetic skin disease that is inherited in an autosomal dominant manner. It is caused by mutations in the ATP2A2 gene, which results in a disturbance in calcium regulation within skin cells. The clinical picture includes keratotic papules that usually appear on seborrheic areas such as the face, scalp, chest, and back. The lesions can be painful and prone to infection. There is currently no known therapy to cure this disease, but proper diagnosis and patient education can greatly facilitate its management. The disease is often associated with psychiatric disorders, including depression and anxiety, which further complicates the condition of sufferers.

DB je rijetka genetska kožna bolest koja se nasljeđuje autosomno dominantno. Uzrokovana je mutacijama u ATP2A2 genu, što rezultira poremećajem u regulaciji kalcija unutar stanica kože. Klinička slika uključuje keratotične papule koje se obično pojavljuju na seboroičnim područjima poput lica, vlasišta, prsa i leđa. Lezije mogu biti bolne i sklone infekcijama. Trenutno ne postoji u potpunosti adekvatna terapija koja bi dovela do izlječenja ove bolesti, međutim pravilna dijagnoza i edukacija pacijenata mogu značajno olakšati njezino upravljanje. Bolest se često povezuje s psihijatrijskim poremećajima, uključujući depresiju i anksioznost, što dodatno komplicira stanje oboljelih.