Osteoarthritis · Osteoarthrosis (OA) is the most common musculoskeletal problem in people age 50. It is characterised by the focal degeneration of joint cartilage and new bone formation at the base of the cartilage lesion (subhondral bone) and at the joint margins (osteophytes). The disease involves entire joint organ (bone, cartilage, supporting elements). Once the diagnosis of OA has been established there are two objectives of therapy: to relieve pain and to preserve function. As so far clinicians have not had effective treatments that alter disease progression, therapy must focus on modifying the symptoms, including the reduction of inflamation, joint pain and functional disability

Osteoartritis · Osteoartroza (OA) najčešći je mišićnokoštani problem u ljudi iznad pedeset godina života. Karakterizirana je fokalnom degeneracijom zglobne hrskavice i formacijom nove kosti u subhondralnom prostoru i na rubovima zglobnih površina. Bolest zahvaća cijeli zglob (kost, hrskavicu, zgobnu čahuru, ligamente, okolne miišiće). Jednom kada se postavi dijagnoza osteoarthritisa, dva su cilja terapije: ukloniti bol i očuvati funkciju. Do danas kliničari nemaju terapiju koja može modificirati progresiju bolesti, tako da je za sada terapija simptomatska. Temelji se na smanjenju upale, smanjenju bola u zglobu i smanjenju funkcionalne onesposobljenosti.