In the present study, biologically active antibacterial coatings based on calcium phosphate (CaP) and polycaprolactone with the addition of chloramphenicol as a model drug have been created. Several physicalmechanical properties have been evaluated such as adhesion strength, hydrophilicity, surface morphology, coating thickness. The results have shown that polycaprolactone addition increases the adhesion strength and elasticity of CaP coating. Images received during scanning electron microscopy demonstrated high surface to volume ratio of CaP coating. The thickness of coating has been increased after addition of polycaprolactone and chloramphenicol compared to unmodified CaP surface. High porosity, better elasticity and stabile antibacterial activity make proposed composite coatings a perspective material for bone replacement surgery.