The effect of atmospheric pressure plasma treatment on properties of polylactic acid films was investigated. Modification was performed in the system for the formation of self-sustained volume discharge with following parameters: pulse voltage 20 kV, pulse energy 0.3 J, pulse repetition frequency 500 Hz, pulse duration 120 ns. Properties of the films were examined by means of wettability analysis and atomic force microscopy. It was shown that plasma treatment change surface morphology and significantly increasing hydrophilicity of scaffolds.