This contribution argues that the great many spatial challenges of our world and the emerging spatial dynamics call for new modes of thinking on regional science research. The creation of a Regional Science Academy may be helpful in meeting this novel demand. The much needed radical and new perspective on the future of our space economy is illustrated by a concise challenging exposition on the consequences of the ongoing "˜New Urban World' which might eventually turn into a "˜Post-Urban World'. The Regional Science Academy may be instrumental in developing such ideas.