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Новые технологии предикции терапии рассеянного склероза

Новые технологии предикции терапии рассеянного склероза

Abstract

Проведено прижизненное исследование мозгового метаболизма у 60 больных рассеянным склероз (РС) с использованием высокопольной протонной магнитно-резонансной спектроскопии и суперпозиционного элктромагнитного сканирования. Дана характеристика процесса демиелинизации в зависимости от воспалительной или дегенеративной фазы заболевания. Выявлен феномен фликерного шума как нового показателя прогредиентности патологического процесса. Получены данные о снижении тканевого дыхания, гипометаболизме нейротрасмиттерных, энергетических и ферментных систем мозга, которые целесообразно использовать в качестве предикции и мониторинга терапии РС.

The study investigates the intravital high-field proton magnetic resonance spectroscopy and superimposed magnetic scanning of brain metabolism in 60 patients showing the association between demyelination activity and the inflammatory or degenerative stage of MS. It also educes Flicker noise phenomenon as a new indicator of a pathologic process progression. The data on the tissue respiration decrease, of the neurotransmitter hypometabolism, energy, and enzyme brain systems were collected to use as the therapy prediction and monitoring of MS.

Keywords

РАССЕЯННЫЙ СКЛЕРОЗ, ПРИЖИЗНЕННАЯ ФУНКЦИОНАЛЬНАЯ НЕЙРОВИЗУАЛИЗАЦИЯ И НЕЙРОМЕТРИЯ, ПРЕДИКЦИЯ И МОНИТОРИНГ ТЕРАПИИ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold