
Низкие (8-30 мкМ) концентрации агонистов н-холинорецепторов левамизола и пирантела вызывают обратимые нарушения функций нервной системы C. elegans, проявляющиеся в нарушениях моторной программы плавания. Чувствительность поведения к действию левамизола выше у C. elegans, чем у C. briggsae, но у C. briggsae выше, чем у C. elegans чувствительность к пирантелу. Отсутствие корреляции изменений чувствительности к левамизолу и пирантелу в эволюции Caenorhabditis объясняется различиями в действии этих нематоцидов, выявляющимися как на организменном, так и молекулярном уровнях.
Low (8-30 μM) concentrations of n-cholinoreceptor agonists of levamisole and pyrantel cause reversible disturbances of C. elegans nervous system functions revealed in damage of the motor program for swimming. C. elegans sensitivity to levamisole is higher than that of C. briggsae, while C. briggsae is more sensitive to pyrantel. The lack of correlation between the sensitivity to levamisole and pyrantel in Caenorhabditis evolution is explained by different action of these nematocides at both organismic and molecular levels.
ЛЕВАМИЗОЛ, ПИРАНТЕЛ, Н-ХОЛИНОРЕЦЕПТОРЫ
ЛЕВАМИЗОЛ, ПИРАНТЕЛ, Н-ХОЛИНОРЕЦЕПТОРЫ
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