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Действие левамизола и пирантела на поведение почвенных нематод Caenorhabditis elegans и Caenorhabditis briggsae

Действие левамизола и пирантела на поведение почвенных нематод Caenorhabditis elegans и Caenorhabditis briggsae

Abstract

Низкие (8-30 мкМ) концентрации агонистов н-холинорецепторов левамизола и пирантела вызывают обратимые нарушения функций нервной системы C. elegans, проявляющиеся в нарушениях моторной программы плавания. Чувствительность поведения к действию левамизола выше у C. elegans, чем у C. briggsae, но у C. briggsae выше, чем у C. elegans чувствительность к пирантелу. Отсутствие корреляции изменений чувствительности к левамизолу и пирантелу в эволюции Caenorhabditis объясняется различиями в действии этих нематоцидов, выявляющимися как на организменном, так и молекулярном уровнях.

Low (8-30 μM) concentrations of n-cholinoreceptor agonists of levamisole and pyrantel cause reversible disturbances of C. elegans nervous system functions revealed in damage of the motor program for swimming. C. elegans sensitivity to levamisole is higher than that of C. briggsae, while C. briggsae is more sensitive to pyrantel. The lack of correlation between the sensitivity to levamisole and pyrantel in Caenorhabditis evolution is explained by different action of these nematocides at both organismic and molecular levels.

Keywords

ЛЕВАМИЗОЛ, ПИРАНТЕЛ, Н-ХОЛИНОРЕЦЕПТОРЫ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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