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Анализ эндотелиальных ритмов микрососудов при хронической обструктивной болезни лёгких

Анализ эндотелиальных ритмов микрососудов при хронической обструктивной болезни лёгких

Abstract

For the dynamic evaluation of endothelial rhythms of microvessels by the method of laser doppler flowmetry there were examined 128 patients of the middle and old age with different course of chronic obstructive pulmonary disease (COPD) and 50 somatically healthy persons of Astrakhanian region. During the recrudescence of COPD it has been determined that the patients of the middle age have the increased amplitude of endothelial rhythms. This activation of microvessels of endothelium was not grading after the treatment of the patients of middle age who had less severe course of COPD. In old age patients the amplitude of endothelial rhythms (Ae=0,260,02 units) and normal values of the amplitude of endothelial rhythms (Ae/ZSKV=6,200,82 units, Аe/PМ=2,760,07 units) were observed, which remained during the decrease of recrudescence.

Для динамической оценки эндотелиальных ритмов микрососудов методом лазерной допплеровской флоуметрии нами было обследовано 128 больных среднего и пожилого возраста с хронической обструктивной болезнью лёгких (ХОБЛ) различного течения и 50 соматически здоровых лиц Астраханского региона. Было выявлено, что при обострении ХОБЛ у больных среднего возраста имеет место увеличение амплитуды эндотелиальных ритмов. Данная активация микрососудистого эндотелия нивелировалась после лечения у больных среднего возраста с ХОБЛ среднетяжелого течения. У пожилых больных с тяжелым течением ХОБЛ, напротив, наблюдалось снижение как абсолютных (Аэ=0,260,02 ед.), так и нормированных показателей амплитуды эндотелиальных ритмов (Аэ/ ЗСКВ=6,200,82 ед., Аэ/ПМ=2,760,07 ед.), которое сохранялось и при стихании обострения.

Keywords

ХРОНИЧЕСКАЯ ОБСТРУКТИВНАЯ БОЛЕЗНЬ ЛЁГКИХ (ХОБЛ), ЛАЗЕРНАЯ ДОППЛЕРОВСКАЯ ФЛОУМЕТРИЯ, МИКРОСОСУДИСТЫЙ ЭНДОТЕЛИЙ, CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average