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Продукция интерферонов у детей с острыми респираторными вирусными инфекциями

Продукция интерферонов у детей с острыми респираторными вирусными инфекциями

Abstract

Резюме. Представлены данные исследования интерферонового статуса у 412 детей и 41 взрослого с острыми респираторными вирусными инфекциями различной этиологии, а также у здоровых 48 детей и 99 взрослых в зависимости от их возраста, индивидуальных особенностей, а также этиологии и характера течения заболевания. Лечебная эффективность препаратов интерферона и его индукторов была изучена у 928 детей. Введены новые показатели оценки интерферонового статуса: индекс стимуляции продукции интерферона и интерферон-продуцирующая активность лимфоцитов, которые дают представление об индивидуальной функциональной активности иммунокомпетентных клеток пациента. Определены критерии назначения интерферонотерапии.

Interferon profile was studied in 412 children and 41 adults with acute respiratory virus infections, as well as in forty-eight healthy children and ninety-nine adults. Appropriate interrelations were evaluated between interferon contents, and age, specific clinical features, etiology and clinical course of the disease. Therapeutic efficiency of interferons and interferon inducers was studied at 928 children. Some novel parameters are proposed to assess interferon state, i.e., stimulation index of interferon production, and interferon-producing activity of lymphocytes that represent individual functional activity of the patients' immunocompetent cells. Criteria for interferon administration

Keywords

ИНТЕРФЕРОН, ИНДУКТОРЫ ИНТЕРФЕРОНА, КЛИНИЧЕСКИЙ ЭФФЕКТ, ИММУНОЛОГИЧЕСКИЕ КРИТЕРИИ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold
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