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Распределение нейромедиаторов в структурах легких после воздействия природным газом

Распределение нейромедиаторов в структурах легких после воздействия природным газом

Abstract

In the science laboratory we have studied the impact of natural gas of different concentrations on bioamino structures of the lungs. Experimental group of laboratory animals was poisoned with natural gas at different concentration: 0.1 of maximum permissible concentration (MPC), a concentration equal to the MPC and a concentration equal to 10 MPC´s. The experiment was conducted daily during 8 hours for 30 days. Luminescent-histochemical methods revealed changes in the content of biogenic amines: serotonin, catecholamine, histamine in the structures of the lungs. Using Pearson correlation analysis to find relationships (dependencies) between the normally distributed quantitative traits, we have revealed correlations between changes in biogenic amines within the cellular structure of the lungs. The damaging effect of natural gas deregulation was emerged in the processes of synthesis and inactivation of neurotransmitters within the cells. Natural gas in the lowest concentration (0.1 MAC) exerted a damaging effect on the investigated structure of the lungs, and with increasing concentrations caused a change in the correlation relationship between biogenic amines inside the cells.

В условиях научной лаборатории было изучено воздействие природного газа различной концентрации на биоаминсодержащие структуры легких. Животные были подвергнуты затравке природным газом концентрацией 0,1 от предельно-допустимой концентрации (ПДК), дозой равной ПДК и дозой в 10 раз превышающей ПДК. Эксперимент проводился ежедневно в течении 8 часов на протяжении 30 суток. Люминесцентно-гистохимическими методами было выявлено изменение содержания биогенных аминов: серотонина, катехоламинов, гистамина в структурах легких. Используя корреляционный анализ Пирсона для нахождения связей (зависимостей) между нормально распределенными количественными признаками, выявили изменение корреляционных связей между биогенными аминами внутри клеточных структур легких. Повреждающее действие природного газа выражалось в разбалансировании процессов синтеза и инактивации нейромедиаторов внутри клеток. Природный газ уже в минимальной концентрации (0,1 ПДК) оказывал повреждающее действие на исследуемые структуры легких, а с увеличением концентрации – вызывал изменения в корреляционных связях между биогенными аминами внутри клеток.

Keywords

НЕЙРОМЕДИАТОРЫ, КОРРЕЛЯЦИОННЫЙ АНАЛИЗ, ГРАНУЛЯРНЫЕ ЛЮМИНЕСЦИРУЮЩИЕ КЛЕТКИ, Т-ЛИМФОЦИТЫ, ПРИРОДНЫЙ ГАЗ, ЛЕГКИЕ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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