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ПЕРСПЕКТИВЫ ИСПОЛЬЗОВАНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ НА ОСНОВЕ ГИДРОБИОНТОВ В ЛЕЧЕНИИ РЕСПИРАТОРНЫХ ВИРУСНЫХ ИНФЕКЦИЙ И ИХ ОСЛОЖНЕНИЙ

ПЕРСПЕКТИВЫ ИСПОЛЬЗОВАНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ НА ОСНОВЕ ГИДРОБИОНТОВ В ЛЕЧЕНИИ РЕСПИРАТОРНЫХ ВИРУСНЫХ ИНФЕКЦИЙ И ИХ ОСЛОЖНЕНИЙ

Abstract

В обзоре представлены сведения о возможности использования биологически активных соединений, в частности пептидов и полисахаридов, из морских гидробионтов в качестве потенциальных источников лекарственных препаратов. Показана их способность воздействовать на основные звенья патогенеза острых респираторных вирусных инфекций. Так, пептиды и гликопептиды оказывают противовоспалительное действие за счет ингибирования циклооксигеназы и ингибирования фосфорилирования МАР-киназы р38, антиоксидантное, иммунокоррегирующее, противовирусное и антибактериальное действия. Обсуждаются перспективы получения новых лекарственных препаратов на основе гликопептидов из морских ежей для лечения инфекций респираторного тракта и их осложнений.

The data of possibilities to use biologically active compounds, peptides and polysaccharides in particular, from sea urchins as potent sources of drugs are represented in the article. Their ability to act on the main chains of pathogenesis of the respiratory viral infections has been shown. So peptides and polysaccharides possess anti-inflammatory action due to inhibition of cyclooxygenase and inhibition of MAP kinase p38 phosphorylation, as well as antioxidant, immune correcting, antiviral and antibacterial effects. The progress in searching new drugs based on glycopeptides from sea urchins for treatment of respiratory tract infections and their complications are discussed.

Keywords

МОРСКИЕ ГИДРОБИОНТЫ,МОРСКИЕ ЕЖИ,РЕСПИРАТОРНЫЕ ВИРУСНЫЕ ИНФЕКЦИИ,ПРОТИВОВИРУСНАЯ АКТИВНОСТЬ ПЕПТИДОВ И ПОЛИСАХАРИДОВ ИЗ МОРСКИХ ЕЖЕЙ,SEA HYDROBIONTS,SEA URCHINS,RESPIRATORY VIRAL INFECTIONS,ANTIVIRAL,ANTI-INFLAMMATORY,ANTIOXIDANT ACTIVITY OF PEPTIDES AND POLYSACCHARIDES FROM SEA URCHINS

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
bronze