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Генерация свободных радикалов и процессы пероксидного окисления липидов в слизистой оболочке желудка крыс в условиях сочетанной нитратной и фторидной интоксикации

Генерация свободных радикалов и процессы пероксидного окисления липидов в слизистой оболочке желудка крыс в условиях сочетанной нитратной и фторидной интоксикации

Abstract

Исследование проведено на 52 половозрелых крысах линии Вистар в течение 30 дней с целью изучения влияния сочетанной нитратной и фторидной интоксикации на генерацию супероксидного анионрадикала (02), функционирование ферментативных антиоксидантных систем, интегральный показатель антиоксидантной защиты и показатели пероксидного окисления липидов (ПОЛ) в слизистой оболочке желудка крыс. Анализ результатов позволил установить синергическое влияние фторидной и нитратной интоксикации на процессы ПОЛ. Влияние на генерацию 02 и антиоксидантные системы имеет более сложное взаимодействие.

The study was conducted on 52 adult Wistar rats for 30 days to examine the effect of combined nitrate and fluoride intoxication on the generation of superoxide anion radical («О?-), the functioning of enzymatic antioxidant systems, integrated indicator of antioxidant protection and indicators of lipid peroxidation (LPO) in rat gastric mucosa. Analysis of the results allowed us to establish a synergistic effect of fluoride and nitrate toxicity on processes of lipid peroxidation. The impact on the generation of »02and antioxidant system has a complex interaction.

Keywords

супероксидный анион-радикал, нанодисперсный кремнезем, нитрат натрия, фторид натрия, супероксиддисмутаза, каталаза, ТБК-реактанты.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average