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Применение рекомбинантного активированного VII фактора свертывания крови для лечения геморрагического синдрома у больных с тромбоцитопенией

Применение рекомбинантного активированного VII фактора свертывания крови для лечения геморрагического синдрома у больных с тромбоцитопенией

Abstract

Приводится обзор литературы, в котором анализируются различные аспекты применения рекомбинантного активированного фактора VII свертывания крови (rFVIIa) для лечения геморрагического синдрома у больных с тромбоцитопенией. Анализируются возможные механизмы действия препарата в условиях тромбоцитопении, методы мониторинга его действия. Приводятся описания применения rFVIIa при кровотечениях различной локализации и инвазивных вмешательствах, анализируются причины возможной неэффективности препарата, частота и причины тромбоэмболических осложнений.

The review deals with an analysis of the use of recombinant activated factor clotting VII (rFVIIa) for the treatment of hemorrhagic syndrome in patients with thrombocytopenia. The review discusses cases of rFVIIa use during bleeding of different localization and different invasive interventions, a frequency of thrombotic complications and causes of the rFVIIa insufficiency.

Keywords

ТРОМБОЦИТОПЕНИЯ, РЕКОМБИНАНТНЫЙ АКТИВИРОВАННЫЙ ФАКТОР VII, ЭФФЕКТИВНОСТЬ, ТРОМБОЭМБОЛИЧЕСКИЕ ОСЛОЖНЕНИЯ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
bronze