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Методология клинико-экспериментального исследования посттравматической репарации верхнечелюстного синуса

Методология клинико-экспериментального исследования посттравматической репарации верхнечелюстного синуса

Abstract

The review analyzed the translational approach in the study of apoptosis factors and their importance in the pathology of the injured mucosa of the maxillary sinus (HFI). The injury and subsequent tissue and triggers metabolic changes in the cells of the mucous membrane of apoptotic death, which correlates with the balance of p53 and Bcl-2 immunoreactivity. Disturbance of this balance can affect the efficiency of the regenerative processes in case of damage. Specific pattern of expression of molecular factors of apoptosis is a key in the mechanisms of regeneration and tissue repair. It is emphasized that the study of this phenomenon in the experiment is radically important to keep in understanding post-traumatic reorganization HFI in humans.

В обзоре анализируются трансляционный подход в исследовании факторов апоптоза и их значение в патологии травмированной слизистой оболочки верхнечелюстной пазухи (ВЧП). Травма и последующие тканевые и метаболические изменения инициируют в клетках слизистой оболочки апоптотическую гибель, которая соотносится с балансом р53и ВД2-иммунореактивности. Нарушение этого баланса может влиять на эффективность регенераторных процессов при повреждении. Специфический паттерн экспрессии молекулярных факторов апоптоза является ключевым в механизмах регенерации и восстановления ткани. Подчеркивается, что изучение этого явления в эксперименте-исключительная важная составляющая в понимании процессов посттравматической реорганизации ВЧП у человека.

Keywords

ЭКСПЕРИМЕНТАЛЬНАЯ ТРАВМА, АПОПТОЗ, РЕГЕНЕРАЦИЯ, ТРАНСЛЯЦИОННАЯ МЕДИЦИНА

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold