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Влияние острой гипобарической гипоксии на репродуктивную функцию лабораторных крыс и мышей сообщение 1: исследование последствий воздействия острой гипобарической гипоксии на стадии раннего органогенеза на жизнеспособность эмбрионов у самок крыс и мышей

Влияние острой гипобарической гипоксии на репродуктивную функцию лабораторных крыс и мышей сообщение 1: исследование последствий воздействия острой гипобарической гипоксии на стадии раннего органогенеза на жизнеспособность эмбрионов у самок крыс и мышей

Abstract

On rats from the strain (HY/Y) low-steady against a hypoxia, deduced and supported in SCBMT of RAMS and on the mice strain C57BL/6Y supported also in collection fund of the Center, investigated consequences of influence of a sharp hypobaric hypoxia on viability of embryos. To acute hypoxia stress of females of both types subjected at the 10th bottom of pregnancy. As a result of the carried-out experiment it is established that the general embryonic mortality was equal in the postimplantation period of development in females of rats of skilled group of 9,5%, at females of mice – 11,2%. Thus the contribution recessive lethal in embryonic mortality at females of rats and at females of mice made 4,36 and 5,1%, respectively. Thus, the share of the lost embryos caused by influence of a hypoxia, equaled at females of rats of 6,0%, at females of mice – 6,1%.

На крысах низкоустойчивой к гипоксии линии (HY/Y), выведенных и поддерживаемых в НЦБМТ РАМН, и на мышах линии C57BL/6Y, поддерживаемых также в коллекционном фонде Центра, исследовали последствия влияния острой гипобарической гипоксии на жизнеспособность эмбрионов. Острому гипоксическому стрессу самок обоих видов подвергали на 10-м дне беременности. В результате проведенного эксперимента установлено, что общая эмбриональная смертность в постимплантационном периоде развития у самок крыс опытной группы была равна 9,5%, у самок мышей – 11,2%. При этом вклад рецессивных леталей в эмбриональную смертность у самок крыс и у самок мышей составил 4,36 и 5,1%, соответственно. Таким образом, доля погибших эмбрионов, обусловленных влиянием гипоксии, равнялась у самок крыс 6,0%, у самок мышей – 6,1%.

Keywords

ОСТРАЯ ГИПОБАРИЧЕСКАЯ ГИПОКСИЯ, РЕЦЕССИВНЫЕ ЛЕТАЛИ, МЫШИ, КРЫСЫ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
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