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Патогенетические аспекты системного воспаления при псориазе с проявлениями ониходистрофии. Обзор литературы

Патогенетические аспекты системного воспаления при псориазе с проявлениями ониходистрофии. Обзор литературы

Abstract

Psoriasis is a chronic inflammatory skin disease characterized by T-cell-mediated hyperproliferation of keratinocytes in the skin. Nail involvement is an extremely common feature of psoriasis and affects approximately 50 % of psoriasis patients with 5–10 % of patients having isolated nail psoriasis. Importantly, 70–90 % of patients with psoriatic arthritis have nail psoriasis. In this overview, we review the clinical manifestations of psoriasis affecting the nails, the common differential diagnosis of nail psoriasis. Nail matrix involvement can result in features such as leukonychia, pitting (punctures or cupuliform depressions), onychoreksis and crumbling. Nail bed involvement, on the other hand, can cause onycholysis, salmon or oil-drop patches, subungual hyperkeratosis, dyschromia and splinter hemorrhages. Participation nail fold can lead to paronychia. Nail psoriasis engenders both physical and psychological handicap, leading to significant negative repercussions in the quality of life.

Псориаз является хроническим воспалительным заболеванием кожи, характеризующимся Т-клеточной гиперпролиферацией кератиноцитов в коже. Изменения ногтей при псориазе встречается практически у половины больных псориазом и у 90 % пациентов с псориатическим артритом. Псориаз ногтей может иметь различные клинические проявления в соответствии со структурой, которая вовлечена в поражение. Участие ногтевой матрицы приводит к симптому наперстка, дистрофии, и лейконихии, линиям Бо, онихорексису. Поражение ногтевого ложа вызывает онихолизис, подногтевой гиперкератоз, осколочные кровоизлияния, дисхромии, масляные пятна, в то время как участие ногтевого валика может привести к паронихиям. Псориаз ногтей приводит к значительному ухудшению качества жизни за счет эстетических проблем и, что более важно, ограничений в повседневной деятельности, нарушая функциональность пальцев.

Keywords

ПСОРИАЗ,ЭТИОПАТОГЕНЕЗ ПСОРИАЗА,ПСОРИАТИЧЕСКАЯ ОНИХОДИСТРОФИЯ,ПСОРИАТИЧЕСКИЙ АРТРИТ,PSORIASIS,PSORIASIS ETIOPATHOGENESIS,PSORIATIC ONYCHODYSROPHY,PSORIATIC ARTHRITIS

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold