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Возможность интраназального применения иммуномодулятора гамма-d-глутамил-l-триптофана у детей раннего возраста с гипертрофией лимфоидного глоточного кольца и с атопической сенсибилизацией к условно-патогенной микрофлоре

Возможность интраназального применения иммуномодулятора гамма-d-глутамил-l-триптофана у детей раннего возраста с гипертрофией лимфоидного глоточного кольца и с атопической сенсибилизацией к условно-патогенной микрофлоре

Abstract

Gamma-D-glutamyl-l-tryptophan activates T-lymphocytes, suppresses replication of viruses, reduces a nonspecific inflammation. This effect was shown for system immunity. In the real research has studied effect of modulating of gamma-D-glutamyl-l-tryptophan on mucosal immunity. On an example of comparison of 43 children receiving gamma-D-glutamyl-l-tryptophan in nose, with 41 children, receiving anti-inflammation therapy, was shown that gamma-D-glutamyl-l-tryptophan possesses modulating effect on immune system of mucous membranes of a nose. Gamma-D-glutamyl-l-tryptophan increased level of IL1-beta, TNF-alpha in a nose secret, reduced degree of a hypertrophy in pharyngeal lymphoid ring and in 1,8 times reduced number of sharp respiratory infections at children of early and preschool age with a hypertrophy of a pharyngeal lymphoid ring and with repeating sharp respiratory infections. This medicine was applied in a nose at children with a hypertrophy a pharyngeal lymphoid ring and with repeating sharp respiratory infections.

Гамма-D-глутамил-L-триптофан активирует Т-лимфоциты, подавляет репликацию вирусов, снижает неспецифическое воспаление. Этот эффект был показан для системного иммунитета. Настоящее исследование было посвящено изучению модулирующего эффекта гамма-D-глутамил-L-триптофана на мукозальный иммунитет. На примере сравнения 43 детей, получавших гамма-D-глутамил-L-триптофан интраназально, с 41 ребенком, получавшим противоспалительную терапию, было показано, что гамма-D-глутамил-L-триптофан обладает модулирующим эффектом на иммунную систему слизистых оболочек носа. Гамма-D-глутамил-L-триптофан увеличивает уровень IL1-beta, TNF-alpha в назальном секрете, снижает степень гипертрофии соответствующих миндалин и в 1,8 раза уменьшает частоту острых респираторных инфекций у детей раннего и дошкольного возраста с гипертрофией лимфоидного глоточного кольца и с рецидивирующими острыми респираторными инфекциями. Гамма-D-глутамил-L-триптофан может применяться детям как местный иммуномодулятор.

Keywords

ГИПЕРТРОФИЯ ЛИМФОИДНОГО ГЛОТОЧНОГО КОЛЬЦА, ИММУНОМОДУЛЯТОР, ГАММА-D-ГЛУТАМИЛ-L-ТРИПТОФАН

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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