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Эффект экзогенной ДНК при экспериментальном раке молочной железы у крыс линии Wistar на пролиферативный потенциал клеток гемои лимфопоэза

Эффект экзогенной ДНК при экспериментальном раке молочной железы у крыс линии Wistar на пролиферативный потенциал клеток гемои лимфопоэза

Abstract

Помимо традиционных цитостатических препаратов при онкологической патологии, в том числе и при раке молочной железы, используют иммуномодуляторы. В последнее время в медицинскую практику внедряются препараты на основе нуклеиновых кислот, в частности Панаген. Однако механизмы влияния фрагментированной ДНК на пролиферативный потенциал клеток гемои лимфопоэза изучены недостаточно. Показано, что при экспериментальном раке молочной железы у крыс линии Wistar терапия фрагментированной ДНК стимулирует спонтанный уровень пролиферации лимфоцитов, снижает спонтанную пролиферацию клеток костного мозга и спленоцитов. В то же время она не оказывает существенного влияния на уровень стимулированной конканавалином А пролиферации лимфоцитов, снижает уровень ответа на митогенный стимул клеток костного мозга и спленоцитов.

In addition to the traditional cytotoxic drugs with cancer, including breast cancer, use of immunomodulators. Recently introduced into medical practice the preparations on the basis of nucleic acids, in particular Panagen. However, the mechanisms of influence fragmented DNA of cell proliferative potential hemo – and lymphopoiesis studied enough. It is shown that experimental breast cancer in rats Wistar therapy fragmented DNA stimulates spontaneous level proliferation of lymphocytes, reduces the spontaneous proliferation of bone marrow cells and splenocytes. At the same time, no significant impact on the level stimulated by concanavalin A proliferation of lymphocytes, reduces the level of mitogenic response to the stimulus of bone marrow cells and splenocytes.

Keywords

ЭКЗОГЕННАЯ ДНК, РАК МОЛОЧНОЙ ЖЕЛЕЗЫ, ПОЛИХИМИОТЕРАПИЯ, ПРОЛИФЕРАЦИЯ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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Cancer Research