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Влияние микроволновой резонансной терапии на структурно-функциональные характеристики эритроцитов больных алкоголизмом

Влияние микроволновой резонансной терапии на структурно-функциональные характеристики эритроцитов больных алкоголизмом

Abstract

В эритроцитах больных алкоголизмом в состоянии абстиненции обнаружено повышенное содержание продуктов перекисного окисления липидов (ПОЛ) и карбонилированных белков, выявлено увеличение амплитуды Са2 + -зависимого гиперполяризационного ответа мембран эритроцитов, обусловленного Са2 + -индуцированным выходом ионов калия через Са2 + -зависимые К + -каналы. После курса микроволновой резонансной терапии (МВРТ) на фоне традиционной дезинтоксикационной терапии в течение 7 дней в эритроцитах пациентов происходит снижение продуктов ПОЛ и карбонилов белков, наблюдается нормализация Са2 + -зависимого гиперполяризационного ответа мембран эритроцитов. В группе больных, которым МВРТ не проводили, через 7 дней дезинтоксикационной терапии достоверных изменений исследуемых параметров эритроцитов не обнаружено. Сделано заключение о способности электромагнитного излучения миллиметрового диапазона оказывать выраженное положительное действие на структурные и функциональные параметры мембран эритроцитов у больных алкоголизмом при микроволновой резонансной терапии.

In erythrocytes of withdrawal alcoholics the increased content of lipid peroxidation products (LPP) and protein carbonyls as well as increase in the amplitude of the Са2 + -induced hyper-polarization of erythrocytes membrane caused by Са2 + -induced efflux К + over Са2 + -sensitive К + -channel (К + (Са2 +)-channel) were revealed. After the 7-days course of microwave resonance therapy (MWRT) combined with traditional detoxicating therapy the content of LPP and protein carbonyls in the alcoholics’ erythrocytes decreased, the Са2 + -induced hyper-polarization of the erythrocyte membrane normalized. Significant changes of the erythrocytes characteristics were not revealed in the group of patients after the 7 days detoxicating therapy course without MWRT treatment. It was concluded that the millimeter range electromagnetic radiation has apparent positive impact on structural-functional characteristics of erythrocytes membrane of alcoholics undergoing the microwave resonance therapy.

Keywords

БЕЛКИ, ЛИПИДЫ, К + (СА2 +)-КАНАЛЫ ЭРИТРОЦИТОВ, МИКРОВОЛНОВАЯ РЕЗОНАНСНАЯ ТЕРАПИЯ, АЛКОГОЛИЗМ, К + (СА2 +)-CHANNEL OF ERYTHROCYTE

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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