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Взаимодействие синтетических производных витамина е на реологические свойства эритроцитарных мембран

Взаимодействие синтетических производных витамина е на реологические свойства эритроцитарных мембран

Abstract

Методами флуоресцентного анализа исследовалось влияние синтетических производных витамина Е тиофана и тиофана-М на реологические свойства мембран эритроцитов. Первый препарат снижал микровязкость как в области липид-липидных, так и белок-липидных взаимодействий. Второй препарат снижал микровязкость в области белок-липидных взаимодействий и повышал в области липид-липидных взаимодействий. Проверка эффективности антиоксидантной защиты эритроцитарных мембран показала, что тиофан значительно подавляет перекисное окисление липидов мембран и образование белково-липидных сшивок, восстанавливая реологические свойства эритроцитов. Данный препарат рекомендован нами для профилактики перекисного окисления липидов у лиц, работающих в условиях Арктики.

Methods of the fluorescent analysis was investigated action of derivatives of vitamin E tiofan and tiofan-M on rheological properties of membranes of erythrocytes. The first formulation reduced the microviscosity of a lipid-lipid, and protein-lipid interactions. The second drug reduced microviscosity of the protein-lipid interactions, and increased in the area of a lipid-lipid interactions. Checking the effectiveness of antioxidant erythrocyte membranes showed that thiophane significantly inhibits peroxidation of membrane lipids and the formation of lipid-protein cross-links, restoring the rheological properties of red blood cells. This drug is recommended by us to prevent lipid peroxidation in persons working in Arctic conditions.

Keywords

МИКРОВЯЗКОСТЬ МЕМБРАН, ПЕРЕКИСНОЕ ОКИСЛЕНИЕ ЛИПИДОВ, ТИОФАН

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold