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Метаболические процессы в лимфоцитах больных острыми респираторными вирусными инфекциями

Метаболические процессы в лимфоцитах больных острыми респираторными вирусными инфекциями

Abstract

Оценка характера и интенсивности метаболических процессов в лимфоцитах больных острыми респираторными вирусными инфекциями с различной степенью тяжести определялась по изменениям активности внутриклеточных ферментов и показала, что в разгар заболевания отмечена разнонаправленность интенсификации реакций пентозофосфатного цикла и гликолиза, а также при значительном повышении функциональной нагрузки на клетки происходит значительное снижение интенсивности реакций начального этапа цикла трикарбоновых кислот, что должно уменьшать энергетическую эффективность цикла, а интенсивное поступление метаболитов для снабжения цикла трикарбоновых кислот субстратами с аминокислотного обмена будет обеспечивать повышенный транспорт аминокислот в лимфоциты.

The estimation of temperament and intensity of metabolic processes in lymphocytes at patients with varying severity of upper respiratory tract infection was determined according to changes of desmoenzymes activity. It showed that the different reacting intensification of pentose phosphate cycle and glycolysis was registered at the height of disease. Also at substantial increase of functional load on cells there is an appreciable reacting intensity depression of initial stage of tricarboxylic acids cycle that should reduce power efficiency of cycle. And intensive admission of metabolites for supply of tricarboxylic acids cycle by substrates of amino-acid exchange will provide the raised transport of amino acids to lymphocytes.

Keywords

ОСТРЫЕ РЕСПИРАТОРНЫЕ ВИРУСНЫЕ ИНФЕКЦИИ, ЛИМФОЦИТЫ, МЕТАБОЛИЧЕСКИЕ ПРОЦЕССЫ, АКТИВНОСТЬ ВНУТРИКЛЕТОЧНЫХ ФЕРМЕНТОВ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average