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Эндокринный профиль мужского населения России в зависимости от географической широты проживания

Эндокринный профиль мужского населения России в зависимости от географической широты проживания

Abstract

The goal of research is to examine the characteristics of the hormones of the pituitary-gonadal and pituitary-thyroid gland systems in the peripheral blood of the male population living in different areas of Russia, taking into account the population groups. The study involved 136 men aged 22 to 50 years old, who are permanently resident in the North no less than three generations. Among them there are 80 local residents of Arkhangelsk (64° 32' N), 19 local residents of Vologda (59° 13' N) and 37 local residents of Nes, Nenets Autonomous Okrug (66° 36' N). According to the basis of nationality group of men living in Nes was divided into: Russian 23 people and settled aboriginal population (Nenets, Komi) 14 people. We have shown that functional activity of the pituitary-thyroid axis (thyrotropin, thyroxine, free triiodothyronine) in the male Caucasoid and settled aboriginal population of the polar region exceeds its level in the inhabitants of the circumpolar area (Arkhangelsk). At the same time, men living in the mid-latitude area (Vologda) had minimal activity of the pituitary-thyroid axis (triiodothyronine, free thyroxine), compared with polar and circumpolar areas. It was shown that the functional activity of the pituitary-gonadal axis in men living in Vologda (luteinizing hormone, follicle-stimulating hormone, inhibin B, free testosterone, dehydroepiandrosterone sulfate) and in Nes (follicle-stimulating hormone, inhibin B, testosterone, free testosterone, sex-hormone-binding globuline) was higher compared with the inhabitants of the city of Arkhangelsk. The levels of sperm antibodies were minimal in men living in Nes. At the same time, changing the traditional way of life from nomadic to a settled one leads to the negative tendencies such as the decrease of the synthesis reserves of steroid hormones in the settled aboriginal population that is shown by the decreased serum levels of progesterone and dehydroepiandrosterone sulfate.

Целью исследования является изучение особенностей содержания в периферической крови гормонов систем гипофиз гонады и гипофиз щитовидная железа у мужского населения различных территорий России с учетом группы населения. Обследовано 136 мужчин в возрасте от 22 до 50 лет, постоянно проживающих на Севере не менее чем в трёх поколениях. Среди них 80 местных жителей г. Архангельска (64° 32'с. ш.), 19 местных жителей г. Вологды (59° 13' с. ш.) и 37 местных жителей пос. Несь Ненецкого автономного округа (66° 36' с. ш.). В пос. Несь группа мужчин была разделена по признаку национальной принадлежности: русские 23 человека и оседлое аборигенное население (ненцы, коми) 14 человек. Нами показано, что функциональная активность системы гипофиз щитовидная железа (тиротропин, тироксин, свободный трийодтиронин) у мужского европеоидного и оседлого аборигенного населения Заполярья превышает ее уровень у жителей приполярных территорий (Архангельск). У мужчин, проживающих на среднеширотных территориях (Вологда), выявлена минимальная активность системы гипофиз щитовидная железа (трийодтиронин, свободный тироксин) по сравнению с таковой у жителей заполярных и приполярных территорий. Показано, что функциональная активность системы гипофиз гонады у мужчин Вологды (лютеинизующий гормон, фолликулостимулирующий гормон, ингибин B, свободный тестостерон, дегидроэпиандростерон-сульфат) и Неси (фолликулостимулирующий гормон, ингибин B, тестостерон, свободный тестостерон, секс-стероидсвязывающий глобулин) выше, чем у жителей г. Архангельска. Уровни антиспермальных антител были минимальными у мужчин Неси. Между тем смена традиционного уклада жизни с кочевого на оседлый приводит к негативным тенденциям снижения резервов синтеза стероидных гормонов у оседлого аборигенного населения, что проявляется снижением уровней прогестерона и дегидроэпиандростерон-сульфата в крови.

Keywords

ГОРМОНЫ,АНТИСПЕРМАЛЬНЫЕ АНТИТЕЛА,СЕКССТЕРОИДСВЯЗЫВАЮЩИЙ ß-ГЛОБУЛИН,СЕВЕР,АДАПТАЦИЯ,МУЖЧИНЫ,HORMONES,SPERM ANTIBODIES,SEX-HORMONE-BINDING GLOBULINE,NORTH,ADAPTATION,MEN

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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