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изучение психоиммуномодулирующего действия сукцината фенотропила в эксперименте

изучение психоиммуномодулирующего действия сукцината фенотропила в эксперименте

Abstract

Резюме. На моделях циклофосфамидной иммунодепрессии и липополисахаридного иммунного стресса были изучены психоиммуномодулирующие свойства нового производного фенотропила сукцината фенотропила при внутрибрюшинном введении различным курсом (от однократного до 7-ми дневного) в разных дозах (25 мг/кг, 50 мг/кг и 100 мг/кг). Установлено, что изучаемое вещество проявляет способность устранять нарушения со стороны различных звеньев иммунной системы. Кроме того, сукцинат фенотропила восстанавливает поведенческие реакции в Суок-тесте. Полученные результаты свидетельствуют об актуальности разработки данного вещества как средства коррекции нейроиммунных нарушенийAbstract. Psychoimmunomodulating properties of phenotropil succinate, a new phenotropil derivative, were studied in a model of cyclophosphamide-induced immunodepression and lypopolysaccharide-induced immune stress, following intraperitoneal injections of the drug at different schedules (from a single injection up to a 7-day course), and at varying doses (25 mg/kg, 50 mg/kg, and 100 mg/kg). It was found that the studied substance shows a clear ability to eliminate disorders of various immune compartments. Moreover, phenotropil succinate was able to restore behavioral reactions in "Suоk-test". These results provide evidence for development of this substance aimed for correction of neuroimmune disturbances.

Keywords

СУКЦИНАТ ФЕНОТРОПИЛА, НЕЙРОИММУНОКОРРЕКЦИЯ, "ИММУННЫЙ" СТРЕСС, ИММУНОДЕПРЕССИЯ, ЦИКЛОФОСФАМИД, ЛИПОПОЛИСАХАРИД, ЭКСПЕРИМЕНТАЛЬНАЯ МОДЕЛЬ, "IMMUNE" STRESS

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold