The aim of the study was to evaluate the efficiency of oxygen-transporting function of cardiovascular system during sevoflurane anesthesia in myocardial revascularization under cardiopulmonary bypass. 25 patients with coronary artery disease were studied. Mean arterial pressure, heart rate, cardiac index, total peripheral resistance, pulmonary artery pressure, pulmonary artery occlusion pressure, central venous pressure, oxygen delivery and consumption, arterio-venous difference in oxygen, the plasma level of glucose and lactate were studied. It was shown that sevoflurane is effective and safe anesthetic for myocardial revascularization under cardiopulmonary bypass. The use of sevoflurane permits to maintain adequate oxygen-transporting function of cardiovascular system during all stages of operation.