Powered by OpenAIRE graph
Found an issue? Give us feedback

Влияние некоторых нейротропных веществ на дыхание митохондрий клеток головного мозга крыс

Влияние некоторых нейротропных веществ на дыхание митохондрий клеток головного мозга крыс

Abstract

В полярографическом исследовании дыхания изолированных митохондрий клеток головного мозга крыс установлено, что новое соединение ИБХФ-2 (примерно в половине случаев), мексидол и амтизола сукцинат способны примерно в равной степени увеличивать скорость потребления кислорода. Другие испытанные новые соединения ИБХФ-1 и ИБХФ-3, а также амтизол и эмоксипин этой способностью не обладают. В отличие от сукцинатсодержащих препаратов (мексидола и амтизола сукцината, стимулирующих дыхание по сукцинатоксидазному пути окисления) ИБХФ-2 стимулирует дыхание митохондрий преимущественно за счет функционирования комплекса I дыхательной цепи.

It was estimated by polarographic measurement of oxygen consumption in rat brain mitochondria that a new substance IBCP-2 (in about a half of all cases), mexidol and amtizol succinate can nearly equally increase oxygen consumption. Other new substances IBCP-1 and IBCP-3 as well as amtizol and emoxipin, have no such ability. Unlike preparations including succinate (mexidol and amtizol succinate), IBCP-2 stimulates mitochondrial respiration by way of complex I.

Keywords

ДЫХАНИЕ МИТОХОНДРИЙ, ПОЛЯРОГРАФИЯ, НЕЙРОТРОПНЫЕ ВЕЩЕСТВА

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold