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Патогенетическая взаимосвязь воспалительных заболеваний пародонта с гастроэзофагеальной рефлюксной болезнью

Патогенетическая взаимосвязь воспалительных заболеваний пародонта с гастроэзофагеальной рефлюксной болезнью

Abstract

Article is devoted to the identification of new diagnostic criteria of inflammatory periodontal diseases (IPD) on the background of GERD based on analysis of clinical, laboratory, morphological and immunohistochemical methods. The study was conducted among 160 patients: 60 patients with IPD against NGERB on the background; 40 patients with IPD on the background EGERB; comparison group – 40 patients with IPD without oesophagus pathology and 20 healthy persons. The result revealed that gingivitis and periodontitis develops against the backdrop of increased number of indicators of NO-synthase and endothelin-1 immunopositive cells. Periodontitis moderate and severe hypoplasia develops in the melatonin immunopositive cells. Periodontal disease on the background of GERD have expressed changes in the components of the diffuse endocrine system. Thus, the nature of periodontal lesions is largely determined by opposite changes of components of diffuse endocrine system. GERD is a risk factor and an unfavorable course of inflammatory periodontal diseases.

Статья посвящена определению новых диагностических критериев воспалительных заболеваний пародонта (ВЗП) на фоне ГЭРБ на основе анализа клинико-лабораторных, морфологических и иммуногистохимических методов. Исследование проводилось среди 160 пациентов: 60 больных c ВЗП на фоне НГЭРБ; 40 больных c ВЗП на фоне ЭГЭРБ; группа сравнения – 40 больных с ВЗП без соматической патологии и 20 практически здоровых лиц. В результате выявлено, что гингивит и пародонтит развиваются на фоне повышенных показателей количества NO-синтаз и эндотелин-1 иммунопозитивных клеток. Пародонтит средней и тяжелой степеней развивается на фоне гипоплазии мелатонин иммунопозитивных клеток. Заболевания пародонта на фоне ГЭРБ имеют выраженные изменения компонентов диффузной эндокринной системы. Таким образом, характер поражения пародонта во многом определяется разнонаправленными изменениями компонентов диффузной эндокринной системы. ГЭРБ является фактором риска и неблагоприятного течения воспалительных заболеваний пародонта.

Keywords

ЗАБОЛЕВАНИЯ ПАРОДОНТА, ГАСТРОЭЗОФАГЕАЛЬНАЯ РЕФЛЮКСНАЯ БОЛЕЗНЬ (ГЭРБ), МЕЛАТОНИН, ЭНДОТЕЛИН-1, NO-СИНТАЗА, GASTROESOPHAGEAL REFLUX DISEASE (GERD)

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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