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Состояние центральной гемодинамики и цереброваскулярные расстройства при идиопатической артериальной гипотензии

Состояние центральной гемодинамики и цереброваскулярные расстройства при идиопатической артериальной гипотензии

Abstract

С целью изучения состояния центрального кровообращения при идиопатической артериальной гипотензии (ИАГ) во взаимосвязи с неврологическими и нейропсихологическими расстройствами обследовано 65 больных (средний возраст 40,2 ± 8,1 года) с длительно существующей ИАГ. Нейропсихологическое обследование включало исследование различных высших психических функций (память, речь, гнозис, праксис, мышление, внимание, счет, письмо, чтение). Центральную гемодинамику оценивали с помощью суточного мониторирования артериального давления (АД) и эхо-кардиографии. Больные без неврологических расстройств составили 1-ю группу (n = 19, 29%), больные с признаками начальных проявлений хронической сосудистой мозговой недостаточности — 2-ю группу (n = 46, 71%). Больные 2-й группы были старше и имели более длительный анамнез ИАГ. Показано, что на фоне стабильно низких показателей систолического и диастолического АД у большинства пациентов был снижен суточный индекс систолического АД по типу non-dippers. У больных обеих групп выявлено повышение сердечного индекса: в 1-й группе — за счет увеличения фракции выброса левого желудочка, во 2-й группе — за счет увеличения частоты сердечных сокращений. Установлена обратная взаимосвязь выраженности нейропсихологических нарушений с показателями систолического и диастолического АД и прямая с индексом времени систолической гипотензии.

A total of 65 patients (mean age 40.2±8.1 yr) with neurologic and neuropsychological disorders associated with long-term idiopathic arterial hypotension (IAH) were studied to estimate the state of their central blood circulation. Neuropsychological conditions were estimated from the state of higher psychic functions, such as memory, speech, gnosis, praxis, cognition, attention, counting, writing, and reading abilities. Central hemodynamics was studied by 24 hr monitoring arterial pressure and echocardiography. Group 1 included patients without neurologic problems (n=19), group 2 consisted of patients with early manifestations of chronic cerebrovascular insufficiency (n=46, 71%). They were older than patients of group 1 and had a long history of IAH. It was shown that most patients presented with stably reduced systolic and diastolic AP and non-dipper type of low 24-hour SAD index. The cardiac index was elevated due to increased left ventricular ejection fraction (group 1) or increased heart rate (group 2). The severity of neuropsychic disorder was negatively related to SAD and DAD indices and positively to systolic hypotension time.

Keywords

ИДИОПАТИЧЕСКАЯ АРТЕРИАЛЬНАЯ ГИПОТЕНЗИЯ, НЕВРОЛОГИЧЕСКИЕ НАРУШЕНИЯ, ЦЕНТРАЛЬНАЯ ГЕМОДИНАМИКА

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold