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Лимфома Ходжкина и «Новый старый» бендамустин

Лимфома Ходжкина и «Новый старый» бендамустин

Abstract

Лимфома Ходжкина злокачественная опухоль, которая с течением времени превратилась из фатальной неизлечимой болезни в успешно излечиваемую в подавляющем большинстве случаев. Тем не менее прогноз у пациентов с рефрактерным и рецидивирующим течением заболевания нередко плохой и угрожающий жизни, в особенности в тех случаях, когда прогрессирование опухоли продолжается после высокодозной химиотерапии с трансплантацией аутологичных гемопоэтических стволовых клеток или, у некоторых пациентов, даже после аллогенной трансплантации костного мозга. Бендамустин «новый старый» цитостатический препарат, который может эффективно применяться для лечения таких больных. Представляемый нами обзор литературы отводит важное место целому ряду новых возможных вариантов лечения лимфомы Ходжкина с применением бендамустина.

Hodgkin’s lymphoma is a malignant tumor that eventually turned from a fatal incurable to successfully curable disease after primary treatment in the vast majority of cases. However, the prognosis for patients with refractory and relapsed disease is not infrequently dismal and life-threatening, especially if the tumor continues progressing after high-dose chemotherapy with autologous stem cell transplantation or, in some instances, even after allogeneic stem cell grafting. Bendamustine is a “new old” cytostatic agent that can be effectively applied for treating this group of patients. Our literature review highlights a variety of relevant options in treatment of Hodgkin’s lymphoma using bendamustine.

Keywords

ЛИМФОМА ХОДЖКИНА, HODGKIN'S LYMPHOMA, РЕЦИДИВ, РЕФРАКТЕРНОЕ ТЕЧЕНИЕ, ЛЕЧЕНИЕ, БЕНДАМУСТИН

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold