Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Sovremennye Issledov...arrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
addClaim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.

Клинико-метаболические аспекты тяжелого течения ОРВИ

Клинико-метаболические аспекты тяжелого течения ОРВИ

Abstract

Purpose. An estimation of character and intensity of metabolic processes in lymphocytes sick осртыми respiratory virus infections on changes of activity of endocellular enzymes depending on weight of a clinical course. Methods. Indicators of enzymes of lymphocytes of 52 patients at the age from 18 till 42 years with the diagnosis a sharp respiratory virus infection were defined. Results. At the height of disease distinctive feature of an intensification of reactions pentozofasfatis a cycle and glikolisis isn'ted, and also at substantial increase of functional loading on cages, there is a considerable decrease in intensity of reactions of the initial stage of a cycle трикарбоновых acids that reduces power efficiency of a cycle, and intensive receipt of metabolites by cycle supply threekarbonis acids substrata with amino acidis an exchange, provides the raised transport of amino acids in lymphocytes. Conclusion. Without the raised possibilities of a lymphocyte to prolesferis, citocinis, antibodies and other humoral factors development of the immune answer adequate to conditions, shown by infectious aggression is impossible for synthesis. Scope of results. Practical public health services, infectious diseases, immunology.

Цель. Оценка характера и интенсивности метаболических процессов в лимфоцитах больных ОРВИ по изменениям активности внутриклеточных ферментов в зависимости от тяжести течения болезни. Методы. Определялись энзиматические показатели лимфоцитов 52 больных в возрасте от 18 до 42 лет с диагнозом острая респираторная вирусная инфекция. Результаты. В разгар заболевания отмечена разнонаправленность интенсификации реакций пентозофосфатного цикла и гликолиза, а также при значительном повышении функциональной нагрузки на клетки, происходит значительное снижение интенсивности реакций начального этапа цикла трикарбоновых кислот, что уменьшает энергетическую эффективность цикла, а интенсивное поступление метаболитов на снабжение ЦТК субстратами с аминокислотного обмена, обеспечивает повышенный транспорт аминокислот в лимфоциты. Вывод. Без повышенных возможностей лимфоцита к пролиферации, синтезу цитокинов, иммуноглобулинов и других гуморальных факторов невозможно развитие иммунного ответа, адекватного условиям, предъявляемым инфекционной агрессией. Область применения результатов. Практическое здравоохранение, инфекционные болезни, иммунология.

Keywords

ОСТРЫЕ РЕСПИРАТОРНЫЕ ВИРУСНЫЕ ИНФЕКЦИИ, ЛИМФОЦИТЫ, МЕТАБОЛИЧЕСКИЕ ПРОЦЕССЫ, АКТИВНОСТЬ ВНУТРИКЛЕТОЧНЫХ ФЕРМЕНТОВ

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold
Related to Research communities