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Использование панели cytodifftm для мониторинга эффективности антивирусной терапии у ВИЧ-инфицированных лиц

Использование панели cytodifftm для мониторинга эффективности антивирусной терапии у ВИЧ-инфицированных лиц

Abstract

В ходе исследования ВИЧ-инфицированныи: лиц с использованием новой пятицветной панели CytoDiff™ для проточной цитофлюориметрии обнаружен дисбаланс в субпопуляциях лейкоцитов. Это проявлялось значительным снижением общего количества лимфоцитов, а также CD16 +-лимфоцитов, В-лимфоцитов и эозинофилов с одновременным повышением уровня CD16 +-моноцитов, нейтрофилов и незрелый: В-лимфоцитов. После проведения высокоактивной антиретровирусной терапии (ВААРТ) у пациентов наблюдалось снижение вирусной нагрузки при одновременном повышении общего уровня лимфоцитов, CD16 +-лимфоцитов, В-лимфоцитов, а также уменьшение количества CD16 +-моноцитов, нейтрофилов и незрелый: В-лимфоцитов.

The study of HIV-infected patients using new five-color panel CytoDiff for flow cytofluorometry revealed the imbalance in subpopulations of leukocytes. The manifestations consisted in significant decrease of total amount of lymphocytes and also CD16+ lymphocytes, B-lymphocytes and eosinocytes with synchronous increase of level of CD16+ monocytes, neutrophils and immature B-lymphocytes. After application to patients of highly active anti-retroviral therapy occurred decrease of viral load under synchronous increase of total level of lymphocytes, CD16+ lymphocytes, B-lymphocytes and also decrease of amount of CD16+ monocytes, neutrophils and immature B-lymphocytes.

Keywords

ВИЧ, ПАНЕЛЬ, CD16+-МОНОЦИТЫ, CD4+-ЛИМФОЦИТЫ, CD16+ MONOCYTES, CD4+ LYMPHOCYTES

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold