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Иммуноморфологический анализ слизистой оболочки полости рта при одонтопрепарировании и табакокурении

Иммуноморфологический анализ слизистой оболочки полости рта при одонтопрепарировании и табакокурении

Abstract

Проведено иммуноморфологическое исследование слизистой оболочки десны в динамике одонтопрепарирования у курящих и некурящих пациентов. Показано, что табакокурение обусловливает более выраженную структурную реорганизацию слизистой оболочки десны, ее атрофические изменения, нарушения процессов внутриклеточной регенерации. Одонтопрепарирование усиливает деструктивные процессы в слизистой оболочке десны, особенно в базальном и шиповатом слоях эпителия, что способствует активации местного иммунитета (усиление синтеза иммуноглобулинов). Выявлены существенные различия гуморального звена местного иммунитета (дисиммуноглобулинемия субклассов IgG) и цитокинового спектра у некурящих и курящих пациентов. Субкомпенсированный уровень иммунной резистентности у курящих людей позволяет выделить их в группу повышенного риска развития хронических патологических процессов полости рта.

Immunomorphological study of oral mucosa in course of odontopreparation in tobacco-smoking and non-smoking patients was carried out. It is shown that tobacco smoking caused a more pronounced structural reorganization of oral mucosa, its atrophic changes and inhibition of the processes of intracellular regeneration. Odontopreparation stimulates destructive processes in the gingival mucosa, especially in basal and tubercular layers, promoting activation of local immunity (stimulation of immunoglobulin synthesis). Significant differences in the local humoral immunity (IgG dysimmunoglobulinemia) and cytokine spectrum in non-smoking and tobacco-smoking patients were detected. Subcompensated level of immune resistance in tobacco smokers prompts referring them to a group at a high risk of chronic pathological processes of the oral cavity.

Keywords

ХРОНИЧЕСКОЕ ВОСПАЛЕНИЕ, СЛИЗИСТАЯ ОБОЛОЧКА ПОЛОСТИ РТА, ОДОНТОПРЕПАРИРОВАНИЕ, ТАБАКОКУРЕНИЕ, МОРФОЛОГИЯ, МЕСТНЫЙ ИММУНИТЕТ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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