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Оценка степени прогрессирования атеросклероза коронарных артерий у пациентов с пятилетним анамнезом инфаркта миокарда в зависимости от приверженности терапии статинами

Оценка степени прогрессирования атеросклероза коронарных артерий у пациентов с пятилетним анамнезом инфаркта миокарда в зависимости от приверженности терапии статинами

Abstract

Цель. Изучить степень прогрессирования атеросклероза коронарных артерий у пациентов с 5-летним анамнезом инфаркта миокарда (ИМ) в зависимости от приверженности терапии статинами. Материал и методы. В исследовании принял участие 31 пациент с 5-летним анамнезом перенесенного ИМ. В зависимости от приверженности терапии статинами пациенты были разделены на две группы: 1 группа пациенты, приверженные терапии статинами в течение 5 лет, 2 группа пациенты, неприверженные терапии статинами. Провели анализ результатов коронароангиографии и показателей липидного профиля в 2005-2006 гг. в период стационарного лечения по поводу ИМ и повторно через 5 лет. Результаты. Несмотря на высокую частоту выполнения чрескожного коронарного вмешательства (77,4%) и приема липидкорригирующей терапии, через 5 лет наблюдения отмечали увеличение доли больных с двухи трехсосудистым поражением. В 11,8% (1 группа) и 21,4% (2 группа) случаев выявлено развитие гемодинамически значимых рестенозов. Целевого уровня общего холестерина крови достигли всего лишь 42,9% и 11,8% пациентов в 1 и 2 группе, соответственно. Целевой уровень холестерина липопротеинов низкой плотности не был достигнут ни в одном случае. Заключение. Полученные данные свидетельствуют о прогрессировании коронарного атеросклероза у пациентов с 5-летним анамнезом ИМ, независимо от приверженности терапии статинами.

Aim. To study the coronary atherosclerosis progression in patients with 5-year history of myocardial infarction (MI) depending on the statin therapy compliance. Material and methods. Patients (n=31) with a five year history of MI were involved into the study. Patients were divided into two groups depending on the statin therapy compliance during 5 years after MI: group 1 patients with high compliance, group 2 patients with low compliance. Assessment of the coronary angiography and lipid profile was performed first time in 2005-2006 during hospital treatment for MI and after 5 years again. Results. Increase in the proportion of patients with two and three coronary vessel disease was found after 5 years of observation, despite the high rate of percutaneous coronary intervention (77.4%) and hypolipidemic therapy. Hemodynamically significant restenosis was found in 11.8% (group 1 ) and 21.4% (group 2) of patients. Target total cholesterol level was reached only in 42.9% and 11.8% of patients in group 1 and 2, respectively. The target level of low density cholesterol was achieved in no one patient. Conclusion. The findings suggest that in patients with 5-year history of MI coronary atherosclerosis progresses regardless of the statin therapy compliance.

Keywords

ИНФАРКТ МИОКАРДА, КОРОНАРОАНГИОГРАФИЯ, ПРИВЕРЖЕННОСТЬ ТЕРАПИИ СТАТИНАМИ, ПРОГРЕССИРОВАНИЕ АТЕРОСКЛЕРОЗА

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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