
Systemic status of thyroid hormones and cortisole was studied in 143 patients having breast cancer (BC), endometrial cancer (EC), lung cancer (LC), nasopharyngeal carcinoma (NPC) and cancer with brain metastases (CBM). The widest range of paraneoplastic shifts and the most frequent occurrence thereof were detected in patients having EC and NPC. As for thyroid panel, the content of total T4 and fT3 (except cases of CBM) was changed under the influence of all variants of the pathology. The content of f T4, total T3 and TTG was disturbed only in patients having EC and NPC, BC, EC and CBM, NPC and CBM, respectively. In all patients having EC and NPC, and in significant number of cases with other sites, hypercortisolemia has been registered (except CBM). The results give evidence of the dependence of hormonal disorders, frequency of detection thereof, direction and degree of intensity in patients having oncopathology on the process localization.
Исследован системный статус тиреоидных гормонов и кортизола у 143 больных раком молочной железы (РМЖ), тела матки (РТМ), лёгкого (РЛ), носоглотки (РНГ) и с метастазами в мозг (МБГМ). Наиболее широкий спектр паранеопластических сдвигов и их частота выявлены у больных РТМ и РНГ. В тиреоидной панели под влиянием всех вариантов патологии изменялось содержание общего Т4 и fT3 ( за исключением МБГМ); содержание свободного fT4, общегоT3 и ТТГ было нарушено только у больных соответственно РТМ и РНГ, и в значительном числе случаев при других локализациях отмечена гиперкортизолемия (кроме МБГМ). Результаты свидетельствуют о зависимости спектра гормональных сбоев, частоты их выявления, направленности и степени выраженности у больных с онкопатологией от локализации процесса.
ВЛИЯНИЕ НА СОДЕРЖАНИЕ В КРОВИ., ЛОКАЛИЗАЦИЯ, ЗЛОКАЧЕСТВЕННЫЕ ОПУХОЛИ, ТИРЕОИДНЫЕ ГОРМОНЫ И КОРТИЗОЛ, INFLUENCE ON CONTENT IN BLOOD.
ВЛИЯНИЕ НА СОДЕРЖАНИЕ В КРОВИ., ЛОКАЛИЗАЦИЯ, ЗЛОКАЧЕСТВЕННЫЕ ОПУХОЛИ, ТИРЕОИДНЫЕ ГОРМОНЫ И КОРТИЗОЛ, INFLUENCE ON CONTENT IN BLOOD.
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