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Особенности паранеопластических нарушений тиреоидного и глюкокортикоидного статуса у больных с разной локализацией опухоли

Особенности паранеопластических нарушений тиреоидного и глюкокортикоидного статуса у больных с разной локализацией опухоли

Abstract

Systemic status of thyroid hormones and cortisole was studied in 143 patients having breast cancer (BC), endometrial cancer (EC), lung cancer (LC), nasopharyngeal carcinoma (NPC) and cancer with brain metastases (CBM). The widest range of paraneoplastic shifts and the most frequent occurrence thereof were detected in patients having EC and NPC. As for thyroid panel, the content of total T4 and fT3 (except cases of CBM) was changed under the influence of all variants of the pathology. The content of f T4, total T3 and TTG was disturbed only in patients having EC and NPC, BC, EC and CBM, NPC and CBM, respectively. In all patients having EC and NPC, and in significant number of cases with other sites, hypercortisolemia has been registered (except CBM). The results give evidence of the dependence of hormonal disorders, frequency of detection thereof, direction and degree of intensity in patients having oncopathology on the process localization.

Исследован системный статус тиреоидных гормонов и кортизола у 143 больных раком молочной железы (РМЖ), тела матки (РТМ), лёгкого (РЛ), носоглотки (РНГ) и с метастазами в мозг (МБГМ). Наиболее широкий спектр паранеопластических сдвигов и их частота выявлены у больных РТМ и РНГ. В тиреоидной панели под влиянием всех вариантов патологии изменялось содержание общего Т4 и fT3 ( за исключением МБГМ); содержание свободного fT4, общегоT3 и ТТГ было нарушено только у больных соответственно РТМ и РНГ, и в значительном числе случаев при других локализациях отмечена гиперкортизолемия (кроме МБГМ). Результаты свидетельствуют о зависимости спектра гормональных сбоев, частоты их выявления, направленности и степени выраженности у больных с онкопатологией от локализации процесса.

Keywords

ВЛИЯНИЕ НА СОДЕРЖАНИЕ В КРОВИ., ЛОКАЛИЗАЦИЯ, ЗЛОКАЧЕСТВЕННЫЕ ОПУХОЛИ, ТИРЕОИДНЫЕ ГОРМОНЫ И КОРТИЗОЛ, INFLUENCE ON CONTENT IN BLOOD.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold
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