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Метаболические изменения в кислородтранспортной системе у пациентов с сахарным диабетом 2 типа. Возможности коррекции

Метаболические изменения в кислородтранспортной системе у пациентов с сахарным диабетом 2 типа. Возможности коррекции

Abstract

Diabetes mellitus type 2 (DM2) is an independent predictor of development of heart failure (HF). Spiroergometry is a method for studying blood gas exchange parameters, commonly used for specification of HF. The purpose: 1. To study features of gas exchange at patients with DM2 without cardiovascular diseases in comparison with healthy control. 2. To estimate efficiency of metoprolol for correction of metabolic disturbances in patients with DM2. Materials and methods: 12 patients with DM2, aged 48,4±8, without history of cardiovascular diseases and 15 control subjects, aged 43,6±8 underwent cardio-pulmonary exercise test on treadmill, according to Bruce protocol. Exercise energy, VO2 peak, MET, VE max, VCO2 production were observed. Results: Patients with DM2 had a reduced exercise duration (p2 production and MET (p2 production (p2 consumption in patients with DM2 is decreased to the same levels as in persons without DM2, who have IHD and HF. 2. Changes in oxygen-transport in persons with DM2 may serve as a marker of negative influence of the disease on cardiovascular system status. 3. Metoprolol improves parameters of cardio-respiratory system in patients with DM2.

Сахарный диабет 2 типа (СД 2) независимый предиктор развития недостаточности кровообращения (НК). Спироэргометрия метод изучения показателей газообмена, используемый для уточнения стадии НК. Цель: 1. Изучить особенности газообмена у пациентов с СД 2 без сердечно-сосудистых заболеваний в сравнении со здоровыми лицами, по данным спироэргометрии. 2. Оценить эффективность метопролола в коррекции метаболических нарушений у больных диабетом. Материалы и методы: в исследование включены 12 пациентов с СД 2 (средний возраст 48,4±8 лет) и 15 лиц без диабета (средний возраст 43,6±9 лет), которым проводилась спироэргометрия по протоколу B. Bruce. Критерием включения в исследование являлось достижение «анаэробного порога» (АП). Результаты: Продолжительность теста до наступления АП была ниже в группе лиц с СД 2 (р2 (р2 у пациентов с СД 2 снижено так же, как у лиц без диабета, имеющих ИБС и НК. 2. Изменения в кислород-транспортной системе у лиц с СД 2 могут служить маркером негативного влияния диабета на состояние сердечно-сосудистой системы 3. Метопролол улучшает показатели кардио-респираторной системы у пациентов с СД 2

Keywords

СД 2, СПИРОЭРГОМЕТРИЯ, КИСЛОРОД-ТРАНСПОРТНАЯ СИСТЕМА, КАРДИО-РЕСПИРАТОРНАЯ СИСТЕМА, МЕТОПРОЛОЛ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
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