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Воспаление и атерогенез. Прогностическое значение маркера сосудистого воспаления липопротеин-ассоциированной фосфолипазы а2 при остром коронарном синдроме

Воспаление и атерогенез. Прогностическое значение маркера сосудистого воспаления липопротеин-ассоциированной фосфолипазы а2 при остром коронарном синдроме

Abstract

Сосудистое воспаление играет ключевую роль в атерогенезе. В связи с этим в кардиологии для клинической оценки пациентов все больше используются биомаркеры, отражающие воспалительные процессы в организме, т. к. их повышение ассоциируется с увеличением риска развития сердечно-сосудистых заболеваний. Определение уровня одного из таких биомаркеров — липопротеин-ассоциированной фосфолипазы А2 (Лп-ФЛA 2) наряду с уже широко используемым С-реактивным протеином обещает значительно повысить выявляемость пациентов высокого риска особенно при остром коронарном синдроме, а также оценить адекватность терапевтических стратегий.

Vascular inflammation plays a key role in atherogenesis. In this regard, in cardiology for clinical evaluation of patients are widely being used biomarkers reflecting inflammation in the organism, as their increasing is associated with an increased risk of cardiovascular disease development. Determining of the level of one of these biomarkers — lipoprotein-associated phospholipase A2 (Lp-FLA2) along with the already widely used C-reactive protein promises to significantly improve the detection of high-risk patients especially in acute coronary syndrome, as well as to assess the adequacy of therapeutic strategy.

Keywords

ОСТРЫЙ КОРОНАРНЫЙ СИНДРОМ, ЛИПОПРОТЕИН-АССОЦИИРОВАННАЯ ФОСФОЛИПАЗА А2, УЯЗВИМАЯ БЛЯШКА, ГОСТРИЙ КОРОНАРНИЙ СИНДРОМ, ЛіПОПРОТЕїН-АСОЦіЙОВАНА ФОСФОЛіПАЗА A2, ВРАЗЛИВА БЛЯШКА

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average