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Лабораторный синтез экспериментальной модели инфаркта миокарда у крыс

Лабораторный синтез экспериментальной модели инфаркта миокарда у крыс

Abstract

The myocardial infarction takes leading positions in structure of mortality and an invalidization of the population of the whole world. Such circumstance draws attention of clinical physicians and the experimenters developing various methods of protection of a myocardium from anoksichesky damage – a cardioprotection. As a rule, mechanisms of a cardioprotection are studied on experimental laboratory models. In article the sequence of expeditious manipulations for receiving experimental model on live rats is described. Experiments are made on 20 nonlinear rats to whom after an anesthesia modelled a necrosis of a cardiac muscle by means of bandaging a back interventricular branch of the right coronary artery. Confirmation of a myocardial infarction carried out by means of electrocardiographic and histologic research. Thus, the method of receiving model of a myocardial infarction offered by us on rats can successfully be used in experimental practice, in particular for studying of mechanisms of a cardioprotection.

Инфаркт миокарда занимает лидирующие позиции в структуре смертности и инвалидизации населения всего мира. Такое обстоятельство привлекает внимание клиницистов и экспериментаторов, разрабатывающих различные методы защиты миокарда от аноксического повреждения – кардиопротекция. Как правило, механизмы кардиопротекции изучаются на экспериментальных лабораторных моделях. В статье описывается последовательность оперативных манипуляций для получения экспериментальной модели на живых крысах. Эксперименты проведены на 20 нелинейных крысах, которым после наркоза моделировали некроз сердечной мышцы посредством перевязки задней межжелудочковой ветви правой коронарной артерии. Подтверждение инфаркта миокарда осуществляли при помощи электрокардиографического и гистологического исследования. Таким образом, предложенный нами метод получения модели инфаркта миокарда на крысах может успешно использоваться в экспериментальной практике, в частности, для изучения механизмов кардиопротекции.

Keywords

ЭКСПЕРИМЕНТАЛЬНЫЙ ИНФАРКТ МИОКАРДА, ДОСТУП К СЕРДЦУ, ГИСТОЛОГИЧЕСКАЯ КАРТИНА

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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