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Морфологические изменения почек при подагрическом гломерулонефрите

Морфологические изменения почек при подагрическом гломерулонефрите

Abstract

THE AIM of the work was to analyze morphological alterations in the kidneys in gouty glomerulonephritis using investigations of bioptates of living patients and sectional findings. PATIENTS AND METHODS. There were 28 histological examinations of the renal tissue, nephrobiopsy was performed in 21 of the patients (1st group). In 7 cases the sectional material was studied taken from corpses of people dead from renal failure (2nd group). Morphological alterations in the renal tissue in gouty glomerulonephritis were assessed. RESULTS. It was found that the alterations in the kidneys of the first group patients corresponded to focal mesangial proliferative (62%) and mesangiocapillary glomerulonephritis (28.6%). Both morphological forms of glomerulonephritis are accompanied by a sharply pronounced tubulointerstitial component. Alterations in the kidneys of the second group reflected nephroangiosclerotic processes. The degree of the alterations in the renal tissue depended on the duration of the disease. CONCLUSION. The data obtained suggest the presence of different variants of glomerular lesions of the kidneys with a sharply pronounced tubulointerstitial components in patients with gout.

ЦЕЛЬ РАБОТЫ заключалась в анализе морфологических изменений почек при подагрическом гломерулонефрите на основании прижизненных исследований биоптатов почек больных и секционных данных. ПАЦИЕНТЫ И МЕТОДЫ. Выполнено 28 гистологических исследований почечной ткани, из них нефробиопсия проведена у 21 больного (1-я группа). В 7 случаях изучали секционный материал людей, умерших от почечной недостаточности (2-я группа). Проведена оценка морфологических изменений почечной ткани при подагрическом гломерулонефрите. РЕЗУЛЬТАТЫ. Установлено, что изменения почек пациентов 1-й группы соответствуют очаговому мезангиальному пролиферативному (62%) и мезангиокапиллярному гломерулонефриту (28,6%). При обоих морфологических формах гломерулонефрита наблюдается резко выраженный тубулоинтерстициальный компонент. Изменения почек во 2-й группе отражают нефроангиосклеротические процессы. Степень выраженности изменений почечной ткани зависит от длительности заболевания. ЗАКЛЮЧЕНИЕ. Полученные данные свидетельствуют о наличии у пациентов с подагрой различных вариантов гломерулярных повреждений почек с резко выраженным тубулоинтерстициальным компонентом.

Keywords

МОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ, ПОДАГРИЧЕСКИЙ ГЛОМЕРУЛОНЕФРИТ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
bronze