
The comprehensive biochemical examination of 20 patients with fractures of shin and thigh bones aged from 18 to 50 years was organized. The treatment consisted of skeletal traction meaning a lingering limitation of locomotive activity. The blood sampled at 7th, 14th, 21th, 28th and 35th days after trauma. The blood plasma was analyzed to establish the indicators of protein and purine metabolism, lipoperoxidation processes and antiradical activity. The study established the catabolic direction of metabolism and the intensification of lipoperoxidation processes of the background of decreasing of antiradical activity. The research data can be recommended to apply in controlling the impact of forced limitation of locomotive activity on the course of post-trauma process.
Проведено комплексное биохимическое обследование 20 больных с переломами костей голени и бедра в возрасте от 18 до 50 лет, которым в качестве лечения был выбран метод скелетного вытяжения, подразумевающий длительное ограничение двигательной активности. Взятие крови проводили на 7, 14, 21, 28 и 35-е сутки после травмы. В плазме крови исследовали показатели белкового, пуринового обмена, процессов липопероксидации (ЛП) и антирадикальной активности. Установлены катаболическая направленность метаболизма, интенсификация процессов ЛП на фоне снижения антирадикальной активности. Полученные данные можно рекомендовать для контроля влияния вынужденного ограничения двигательной активности на течение посттравматического процесса.
ГИПОДИНАМИЯ, БЕЛКОВЫЙ ОБМЕН, ПУРИНОВЫЙ ОБМЕН, ЛИПОПЕРОКСИДАЦИЯ, АНТИРАДИКАЛЬНАЯ АКТИВНОСТЬ
ГИПОДИНАМИЯ, БЕЛКОВЫЙ ОБМЕН, ПУРИНОВЫЙ ОБМЕН, ЛИПОПЕРОКСИДАЦИЯ, АНТИРАДИКАЛЬНАЯ АКТИВНОСТЬ
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